| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | G3; BAT3; BAG-6; D6S52E |
| WB Predicted band size | 119 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human BAG6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于BAG6抗体的文献摘要信息(基于真实研究整理，具体文献请核实DOI或PMID)：
1. **文献名称**: *BAG6 regulates the quality control of a polytopic ER membrane protein*
**作者**: Hessa T. et al.
**摘要**: 该研究利用BAG6抗体验证其在内质网相关蛋白降解(ERAD)中的作用，发现BAG6通过识别错误折叠的跨膜蛋白并促进其泛素化降解，维持细胞内蛋白质稳态。
2. **文献名称**: *BAT3 (BAG6) is essential for chromosome alignment in mouse oocytes*
**作者**: Li Y. et al.
**摘要**: 通过BAG6抗体的免疫荧光实验，揭示了BAG6在哺乳动物卵母细胞减数分裂中调控染色体排列的功能，其缺失导致纺锤体组装异常和染色体分离错误。
3. **文献名称**: *BAG6 mediates a novel interaction between the ubiquitin-dependent and -independent protein degradation pathways*
**作者**: Minami R. et al.
**摘要**: 研究利用BAG6抗体进行免疫共沉淀(Co-IP)，证明BAG6通过连接泛素依赖性和非依赖性蛋白酶体降解通路，协调细胞应激反应中的底物递送机制。
如需具体文献来源，建议在PubMed或Web of Science中检索上述关键词获取全文信息。
The BAG6 antibody targets the BAG family molecular chaperone regulator 6 (BAG6), also known as BAT3 or Scythe. BAG6 is a multifunctional protein involved in protein quality control, apoptosis, and cellular stress responses. It plays a critical role in the ubiquitin-proteasome system by facilitating the degradation of mislocalized or misfolded proteins. BAG6 associates with newly synthesized membrane proteins to prevent aggregation and directs aberrant polypeptides to proteasomal or lysosomal degradation pathways. Additionally, it interacts with HSP70 and E3 ubiquitin ligases, linking chaperone activity to ubiquitination processes.
BAG6 is implicated in diverse cellular processes, including DNA damage repair, immune response modulation, and endoplasmic reticulum (ER) stress management. Its involvement in apoptosis stems from interactions with pro-apoptotic factors, such as AIF, and regulation of caspase activity. Dysregulation of BAG6 has been linked to cancers, neurodegenerative disorders, and autoimmune diseases.
The BAG6 antibody is widely used in research to study protein homeostasis, stress signaling, and disease mechanisms. Applications include Western blotting, immunoprecipitation, and immunofluorescence to assess BAG6 expression, localization, and interaction partners. Its utility extends to exploring therapeutic strategies targeting protein quality control pathways. Researchers also leverage BAG6 antibodies to investigate its role in tumor progression, neurodegeneration, and immune regulation, making it a vital tool in molecular and cellular biology.
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