| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | PDI, PDA2, PDIP, PDIR |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PDIA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PDIA2抗体相关的文献示例(注：内容为模拟概括，具体文献需根据实际数据库查询)：
1. **文献名称**：*"PDIA2 promotes gastric cancer progression through IL-6/STAT3 signaling pathway"*
**作者**：Li, X. et al.
**摘要**：研究揭示了PDIA2在胃癌组织中的过表达现象，通过PDIA2抗体检测发现其通过激活IL-6/STAT3通路促进肿瘤增殖和转移，提示PDIA2可能成为治疗靶点。
2. **文献名称**：*"PDIA2 interacts with the hepatitis C virus NS5A protein and regulates viral replication"*
**作者**：Wang, Y. et al.
**摘要**：利用PDIA2抗体进行免疫共沉淀实验，发现PDIA2与HCV病毒NS5A蛋白相互作用，调控病毒复制，为抗病毒治疗提供了新方向。
3. **文献名称**：*"PDIA2 as a novel diagnostic biomarker for pancreatic cancer: A comparative study using immunohistochemistry"*
**作者**：Zhang, R. et al.
**摘要**：通过PDIA2抗体对胰腺癌组织进行免疫组化分析，发现PDIA2在癌变组织中显著高表达，可作为潜在的早期诊断标志物。
4. **文献名称**：*"Structural and functional analysis of PDIA2 in oxidative protein folding"*
**作者**：Chen, L. et al.
**摘要**：研究利用PDIA2抗体进行亚细胞定位和功能抑制实验，阐明PDIA2在内质网氧化折叠通路中的关键作用及其底物特异性。
(提示：实际文献请通过PubMed、Web of Science或Google Scholar检索具体标题验证。)
The PDIA2 antibody targets Protein Disulfide Isomerase Family A Member 2 (PDIA2), a member of the protein disulfide isomerase (PDI) family. PDIA2. also known as PDIR, is an endoplasmic reticulum (ER)-resident oxidoreductase involved in catalyzing disulfide bond formation, isomerization, and reduction during protein folding. It plays a critical role in maintaining ER homeostasis by assisting in the proper folding of secretory and membrane proteins, particularly in high-secreting cells like pancreatic, intestinal, or immune cells. Structurally, PDIA2 contains thioredoxin-like domains with catalytic CXXC motifs essential for its enzymatic activity.
PDIA2 expression is often upregulated under ER stress conditions, linking it to diseases such as cancer, diabetes, and inflammatory disorders. Studies suggest its involvement in modulating immune responses, including antigen presentation and cytokine production. The PDIA2 antibody is widely used in research to investigate protein folding mechanisms, ER stress pathways, and disease-associated dysregulation. Applications include Western blotting, immunohistochemistry, and immunofluorescence to localize PDIA2 in tissues or cells. Its specificity and validation are crucial for distinguishing PDIA2 from other PDI family members, which share structural similarities but exhibit distinct functional roles. Recent research also explores PDIA2 as a potential therapeutic target or biomarker in pathologies linked to proteostasis imbalance.
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