Rabbit Polyclonal PSMD6 Antibody

The PSMD6 (Proteasome 26S Subunit, Non-ATPase 6) antibody is a research tool targeting the PSMD6 protein, a critical component of the 26S proteasome. The 26S proteasome, comprising a 20S catalytic core and 19S regulatory particles, mediates ubiquitin-dependent protein degradation, essential for cellular homeostasis, protein quality control, and regulated processes like cell cycle progression. PSMD6. part of the 19S regulatory complex, aids in substrate recognition, deubiquitination, and ATPase-dependent unfolding of target proteins. Dysregulation of proteasomal activity is linked to cancers, neurodegenerative diseases, and immune disorders. PSMD6 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to study proteasome assembly, function, and disease associations. They help investigate PSMD6’s role in cancer progression, as overexpression is observed in certain malignancies, correlating with cell proliferation and chemoresistance. These antibodies are also employed in exploring neurodegenerative pathways, such as aberrant protein aggregation in Alzheimer’s or Parkinson’s disease. Validated PSMD6 antibodies exhibit specificity for human, mouse, or rat samples, often confirmed via knockout controls. Commercial variants may differ in clonality (monoclonal/polyclonal), conjugates (e.g., HRP, fluorescent tags), and applications, requiring careful selection based on experimental needs. Research utilizing PSMD6 antibodies contributes to understanding proteostasis mechanisms and therapeutic targeting of proteasome dysfunction.