| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | STX1; HPC-1; P35-1; SYN1A |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human STX1A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于STX1A抗体的3篇参考文献示例(注：部分信息为模拟虚构，实际文献需通过数据库核实)：
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1. **标题**: *Syntaxin-1A modulates vesicle fusion in neurodegenerative disorders*
**作者**: Smith J, et al.
**摘要**: 本研究利用STX1A特异性抗体，通过免疫印迹和免疫荧光技术，发现阿尔茨海默病小鼠模型中STX1A蛋白表达显著下调，提示其与突触功能障碍相关。
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2. **标题**: *Role of STX1A in pancreatic β-cell exocytosis*
**作者**: Chen L, et al.
**摘要**: 通过STX1A抗体的免疫共沉淀实验，揭示了STX1A与SNAP-25蛋白的相互作用对胰岛素分泌的关键调控作用，为糖尿病治疗提供新靶点。
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3. **标题**: *STX1A antibody-based profiling in autism spectrum disorder*
**作者**: Park S, et al.
**摘要**: 采用STX1A抗体对人脑组织样本进行免疫组化分析，发现自闭症患者前额叶皮层中STX1A分布异常，提示突触囊泡运输异常可能参与疾病机制。
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**提示**：建议通过PubMed或Google Scholar搜索关键词“STX1A antibody” + “Western blot/immunohistochemistry”等实验方法，筛选近5年高引用文献以获取准确信息。
The STX1A (Syntaxin-1A) antibody is a tool used to detect Syntaxin-1A, a key protein involved in neurotransmitter release and synaptic vesicle fusion. Syntaxin-1A belongs to the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family, which mediates membrane fusion events critical for intracellular transport and exocytosis. Primarily expressed in neuronal tissues, Syntaxin-1A localizes to presynaptic membranes, interacting with proteins like SNAP-25 and synaptobrevin to form the SNARE complex, enabling vesicle docking and calcium-triggered neurotransmitter release. Dysregulation of Syntaxin-1A is linked to neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy, making it a focus of neurobiological research.
STX1A antibodies are widely employed in studies exploring synaptic function, protein interactions, and disease mechanisms. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping visualize expression levels, subcellular localization, and alterations in pathological conditions. Commercial STX1A antibodies are typically raised in rabbits or mice, targeting specific epitopes within the protein’s N-terminal or C-terminal domains. Validation steps, such as knockout controls, ensure specificity. Beyond research, STX1A antibodies hold potential in diagnostic applications, aiding biomarker identification for neurodegenerative diseases, and in drug development targeting synaptic transmission pathways.
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