| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | BIE; EHK; K10; KPP; BCIE; CK10 |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human KRT10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KRT10抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *"Keratin 10-Specific Autoantibodies in Patients with Chronic Graft-Versus-Host Disease"*
**作者**: Magro CM, Momtahen S (2018)
**摘要**: 该研究探讨了慢性移植物抗宿主病(cGVHD)患者中抗KRT10自身抗体的存在。通过免疫组化和蛋白质印迹分析，发现患者血清中KRT10抗体与表皮角化细胞的特异性结合，提示其可能作为cGVHD的生物标志物。
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2. **文献名称**: *"Immunohistochemical Analysis of Keratin 10 in Epidermal Tumors and Inflammatory Skin Diseases"*
**作者**: Ishida-Yamamoto A, et al. (2005)
**摘要**: 研究利用KRT10抗体评估其在多种表皮肿瘤(如鳞状细胞癌)和炎症性皮肤病(如银屑病)中的表达模式。结果显示KRT10在分化良好的肿瘤细胞中高表达，但在银屑病皮损中表达降低，提示其与角质形成细胞分化状态相关。
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3. **文献名称**: *"Antibody Validation for Keratin 10 in Human and Mouse Tissues"*
**作者**: Lessard JC, Coulombe PA (2012)
**摘要**: 该文献系统验证了多种KRT10抗体的特异性，通过比较人源和小鼠组织中的免疫染色结果，确认了某些单克隆抗体在福尔马林固定石蜡包埋样本中的可靠性，为后续研究提供了标准化实验依据。
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**注**：以上文献信息为示例性质，实际引用时需根据具体文献数据库(如PubMed、Web of Science)核对原文准确性。若需更近期或特定研究方向的文献，建议结合关键词“KRT10 antibody”及研究领域进一步筛选。
The KRT10 antibody targets keratin 10 (KRT10), a member of the type I keratin family, which plays a critical role in maintaining epidermal integrity. KRT10 pairs with keratin 1 (KRT1) to form intermediate filaments in the suprabasal layers (spinous and granular) of stratified epithelial cells, providing mechanical stability and regulating cell differentiation. Its expression is tightly linked to the terminal differentiation program of keratinocytes, making it a marker for epidermal maturation.
In research and diagnostics, the KRT10 antibody is widely used to study skin biology and pathologies. It helps identify aberrant keratinization in conditions like psoriasis, ichthyosis, and certain skin cancers. Mutations in the KRT10 gene are associated with autosomal dominant disorders such as epidermolytic hyperkeratosis (EHK), characterized by blistering and hyperthickened skin. The antibody aids in detecting these mutations’ effects on protein expression and cellular structure.
Additionally, KRT10 antibodies are employed in immunohistochemistry to differentiate epidermal-derived tumors from other malignancies, as its loss or abnormal expression often correlates with dedifferentiation in squamous cell carcinomas. Beyond dermatopathology, it serves as a tool in developmental biology to map epithelial differentiation processes. Its specificity and relevance in epithelial tissue homeostasis underscore its utility in both basic research and clinical applications.
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