Rabbit Polyclonal ACO2 Antibody

The ACO2 antibody is a tool used to detect aconitase 2. a mitochondrial enzyme critical in the tricarboxylic acid (TCA) cycle. Aconitase 2 (ACO2) catalyzes the isomerization of citrate to isocitrate, a key step in cellular energy production. Beyond its metabolic role, ACO2 also participates in iron homeostasis, functioning as an iron-sulfur cluster protein and potentially acting as a sensor for oxidative stress. Dysregulation of ACO2 has been linked to metabolic disorders, neurodegenerative diseases (e.g., Alzheimer's, Parkinson's), and certain cancers. The ACO2 antibody enables researchers to study protein expression, localization, and function in tissues or cultured cells through techniques like Western blotting, immunohistochemistry, and immunofluorescence. It has become particularly valuable in investigating mitochondrial dysfunction and iron metabolism abnormalities. Mutations in the ACO2 gene are associated with autosomal recessive aconitase deficiency, characterized by encephalopathy and cerebellar atrophy, making this antibody relevant for both basic research and clinical diagnostics. Recent studies also explore its potential as a biomarker in cancer metabolism studies, particularly in tumors reliant on altered TCA cycle activity.