Rabbit Polyclonal ADORA2A Antibody

The ADORA2A antibody is a crucial tool in neuroscience and molecular biology research, targeting the adenosine A2A receptor (ADORA2A), a G protein-coupled receptor (GPCR) that binds adenosine. This receptor plays a significant role in modulating neurotransmitter release, neuroinflammation, and cardiovascular function. ADORA2A is highly expressed in the brain, particularly in the striatum, and is involved in dopamine signaling pathways, making it a key focus in studies of Parkinson’s disease, addiction, and cognitive disorders. In peripheral tissues, it regulates immune responses and vascular tone. Researchers utilize ADORA2A antibodies to detect receptor expression, localization, and dynamics in cell lines, tissues, or animal models via techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry. These antibodies are often validated for specificity through knockout controls or competitive binding assays. Recent studies also explore ADORA2A as a therapeutic target, with antagonists investigated for neurodegenerative diseases and cancer immunotherapy. Commercially available ADORA2A antibodies are typically raised in hosts like rabbits or mice, targeting epitopes in extracellular or intracellular domains. Proper validation ensures reliability in distinguishing ADORA2A from closely related receptors (e.g., ADORA1 or ADORA2B), minimizing cross-reactivity. Its applications extend to drug development, biomarker research, and mechanistic studies of adenosine signaling pathways.