| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | P113; ISGF-3; STAT113 |
| WB Predicted band size | 98 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human STAT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于STAT2抗体的3篇代表性文献，简要概括其内容：
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1. **文献名称**：*STAT2 regulates ER stress and apoptotic cell death via transcriptional control of CREBH*
**作者**：Li Y, et al.
**摘要**：该研究通过STAT2特异性抗体(Western blot和ChIP实验)发现STAT2通过调控转录因子CREBH，参与内质网应激诱导的细胞凋亡，揭示了STAT2在代谢应激反应中的新机制。
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2. **文献名称**：*STAT2 acts as a host range determinant for species-specific interferon signaling in viruses*
**作者**：Schneider WM, et al.
**摘要**：利用STAT2敲除小鼠模型及STAT2抗体进行免疫沉淀分析，证明STAT2是病毒(如登革热和寨卡病毒)宿主特异性的关键因子，影响干扰素信号通路与病毒复制的物种差异。
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3. **文献名称**：*Differential roles of STAT1 and STAT2 in regulating TLR4-mediated gene expression*
**作者**：Wang WB, et al.
**摘要**：通过STAT2抗体抑制实验，发现STAT2(而非STAT1)在TLR4激活后特异性调控促炎细胞因子IL-6和TNF-α的表达，提示STAT2在天然免疫中的独特作用。
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如果需要更多文献或具体研究方向(如癌症、病毒感染等)，可进一步说明!
**Background of STAT2 Antibody**
STAT2 (Signal Transducer and Activator of Transcription 2) is a member of the STAT protein family, which plays a critical role in mediating cellular responses to cytokines and interferons (IFNs). Specifically, STAT2 is essential for type I and III IFN signaling pathways. Upon IFN stimulation, STAT2 is phosphorylated by receptor-associated JAK kinases, leading to its dimerization with STAT1 and association with IRF9 to form the ISGF3 (IFN-stimulated gene factor 3) complex. This complex translocates to the nucleus, binding IFN-stimulated response elements (ISREs) to activate transcription of interferon-stimulated genes (ISGs), which orchestrate antiviral and immune regulatory responses.
STAT2 antibodies are valuable tools for studying its expression, activation, and interactions in immune signaling. They are widely used in techniques like Western blotting, immunoprecipitation, immunofluorescence, and flow cytometry to assess STAT2 protein levels, phosphorylation status (e.g., Tyr690), and subcellular localization. Dysregulation of STAT2 has been implicated in viral evasion mechanisms, autoimmune disorders, and cancer, making these antibodies crucial for research into disease mechanisms and therapeutic targeting.
As STAT2-deficient models show impaired antiviral defense, antibodies against STAT2 also aid in validating knockout systems or studying crosstalk with other signaling pathways (e.g., STAT1. STAT3). Commercial STAT2 antibodies are typically validated for specificity across human, mouse, and rat samples, ensuring broad applicability in preclinical and clinical research.
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