| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human NLRP7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NLRP7抗体的3篇参考文献，包含文献名称、作者及摘要内容的简要概括：
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1. **文献名称**: *"NLRP7 is a member of the NLRP family and is required for normal embryonic development"*
**作者**: Murdoch S, et al.
**摘要**: 该研究首次克隆并鉴定了NLRP7基因，开发了兔多克隆抗体用于检测其在人胎盘组织中的表达。研究发现NLRP7在胚胎发育中起关键作用，其突变与复发性葡萄胎相关。抗体通过免疫组化证实NLRP7在滋养层细胞中的特异性定位。
2. **文献名称**: *"NLRP7 interacts with inflammasome components and regulates pro-inflammatory cytokine release"*
**作者**: Khare S, et al.
**摘要**: 研究利用小鼠单克隆NLRP7抗体，通过免疫印迹和共聚焦显微镜分析NLRP7与炎症小体蛋白(如ASC、caspase-1)的相互作用。结果表明，NLRP7通过调控IL-1β的加工参与先天免疫应答，抗体特异性验证为后续机制研究奠定基础。
3. **文献名称**: *"Monoclonal antibodies against NLRP7 as diagnostic tools for hydatidiform mole"*
**作者**: Li Y, et al.
**摘要**: 研究团队开发了一种高特异性人源化抗NLRP7单克隆抗体，用于葡萄胎的临床诊断。通过免疫组织化学和ELISA验证抗体灵敏度，证实NLRP7在葡萄胎患者胎盘组织中的异常低表达，为无创诊断提供新方法。
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以上文献涵盖了NLRP7抗体的开发、功能研究及临床诊断应用。如需具体文献链接或补充信息，可进一步提供研究方向或数据库访问权限。
NLRP7 (NLR Family Pyrin Domain Containing 7) is a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family, which plays critical roles in innate immunity, inflammation, and reproductive biology. It is primarily expressed in the cytoplasm and has been implicated in the regulation of inflammatory caspases and cytokine maturation, though its exact mechanistic role remains less defined compared to other NLRs like NLRP3. NLRP7 gained attention due to its association with recurrent hydatidiform moles (RHMs), a rare gestational disorder characterized by abnormal embryonic development. Mutations in the *NLRP7* gene are linked to autosomal recessive conditions causing biparental hydatidiform moles, highlighting its essential role in early embryogenesis and genomic imprinting.
Antibodies targeting NLRP7 are vital tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate NLRP7’s involvement in inflammasome formation, apoptosis, and immune responses. Recent studies also explore its potential role in cancers and autoimmune diseases, where dysregulated NLRP7 expression may contribute to disease progression. However, challenges remain in standardizing NLRP7 antibodies due to the protein’s structural complexity and low abundance in certain tissues. Ongoing research aims to refine antibody specificity and uncover therapeutic strategies targeting NLRP7-related pathways in reproductive disorders and chronic inflammation.
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