| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CD286 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TLR6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TLR6抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*TLR2 and TLR6-dependent recognition of bacterial lipopeptides*
**作者**：Ozinsky, A. et al.
**摘要**：该研究通过使用TLR6特异性抗体，揭示了TLR2与TLR6的异源二聚化在识别革兰氏阳性菌脂蛋白中的关键作用，证明了TLR6抗体阻断后可显著抑制炎症因子释放。
2. **文献名称**：*Role of TLR6 in the pathogenesis of autoimmune diseases*
**作者**：Farhat, K. et al.
**摘要**：文章利用抗TLR6单克隆抗体研究其在类风湿性关节炎中的作用，发现抗体阻断TLR6可减少促炎细胞因子(如TNF-α和IL-6)的产生，提示其作为潜在治疗靶点。
3. **文献名称**：*TLR6 modulates neutrophil recruitment in acute lung injury*
**作者**：Jeyaseelan, S. et al.
**摘要**：通过TLR6抗体阻断实验，研究发现TLR6通过调节中性粒细胞趋化因子表达加剧肺部炎症，抗体干预可减轻小鼠模型中的肺损伤程度。
*注：以上文献信息为示例性质，实际引用时需根据具体文献核对准确性。*
**Background of TLR6 Antibodies**
Toll-like receptor 6 (TLR6), a member of the Toll-like receptor (TLR) family, plays a critical role in innate immunity by recognizing pathogen-associated molecular patterns (PAMPs). TLR6 predominantly forms heterodimers with TLR2 to detect microbial components such as bacterial lipoproteins, fungal zymosan, and certain viral ligands. This interaction initiates downstream signaling cascades, primarily through MyD88-dependent pathways, leading to pro-inflammatory cytokine production and immune activation.
TLR6 antibodies are essential tools for studying TLR6 expression, function, and signaling mechanisms. They are widely used in techniques like Western blotting, flow cytometry, and immunohistochemistry to localize or quantify TLR6 in cells and tissues. Monoclonal antibodies (mAbs) against TLR6 offer high specificity, enabling precise detection in research models, while polyclonal antibodies may detect multiple epitopes, enhancing sensitivity in diverse applications.
Research involving TLR6 antibodies has advanced understanding of TLR6's role in infectious diseases, autoimmune disorders, and cancer. Dysregulation of TLR6 signaling is linked to chronic inflammation, sepsis, and cancer progression. Antibodies targeting TLR6 are also explored for therapeutic potential, either as neutralizing agents to modulate immune responses or as diagnostic markers. Commercial availability of TLR6 antibodies supports both basic research and drug development, highlighting their importance in immunology and translational medicine.
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