| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ADFP; ADRP |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human PLIN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PLIN2抗体相关的文献示例(内容为模拟，建议通过数据库核实具体文献)：
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1. **文献名称**：*"Role of PLIN2 in hepatic lipid droplet metabolism in non-alcoholic fatty liver disease"*
**作者**：Smith A, et al.
**摘要**：研究利用PLIN2特异性抗体，通过免疫组化和Western blot技术，揭示了PLIN2在非酒精性脂肪肝(NAFLD)患者肝脏脂滴积累中的关键作用，并发现其表达与疾病严重程度正相关。
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2. **文献名称**：*"PLIN2-mediated lipid storage promotes prostate cancer progression"*
**作者**：Chen L, et al.
**摘要**：该研究通过PLIN2抗体进行免疫荧光染色和流式细胞术，证明前列腺癌细胞中PLIN2高表达与脂代谢重编程相关，促进肿瘤生长和化疗抵抗。
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3. **文献名称**：*"Antibody-based detection of PLIN2 reveals its interaction with autophagy proteins in adipocytes"*
**作者**：Wang Y, et al.
**摘要**：利用PLIN2抗体进行共聚焦显微镜观察和免疫共沉淀实验，发现PLIN2通过与自噬相关蛋白(如LC3)相互作用参与脂滴降解，为肥胖治疗提供新靶点。
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**备注**：以上为示例，实际文献需通过PubMed、Google Scholar等平台检索关键词“PLIN2 antibody”或“Perilipin-2”获取。
The PLIN2 antibody is a crucial tool for studying perilipin 2 (PLIN2), a lipid droplet-associated protein also known as adipocyte differentiation-related protein (ADRP). PLIN2 belongs to the PAT family of proteins, which regulate lipid storage and metabolism by coating intracellular lipid droplets, stabilizing their structure, and modulating lipolysis. It is ubiquitously expressed in tissues with high lipid turnover, including adipose tissue, liver, and macrophages. PLIN2 plays a key role in lipid homeostasis, influencing cellular responses to nutrient availability and stress. Dysregulation of PLIN2 is implicated in metabolic disorders such as atherosclerosis, obesity, non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes. It has also been linked to cancer progression due to its role in lipid-driven signaling pathways.
PLIN2 antibodies are widely used in research to detect and quantify PLIN2 expression via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence. These antibodies help elucidate PLIN2's interaction with other lipid metabolism regulators (e.g., PPARs, lipases) and its involvement in pathological lipid accumulation. Monoclonal antibodies offer high specificity, while polyclonal versions may detect broader epitopes. Validated PLIN2 antibodies are essential for studying lipid droplet dynamics, metabolic adaptations, and therapeutic targets for diseases linked to lipid metabolism dysregulation. Their application spans basic research, preclinical models, and clinical investigations, underscoring PLIN2's significance in cellular and systemic energy balance.
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