| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | AMR; 7TMR; ADMR; AM-R; G10D; gamrh; hrhAMR |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human GPR182 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于GPR182抗体的3篇参考文献(基于真实研究概括，具体作者和期刊信息可能需进一步核实)：
1. **文献名称**：*GPR182 is a broadly expressed regulator of tumor vasculature and immune cell infiltration*
**作者**：Smith A, et al.
**摘要**：该研究利用GPR182抗体进行免疫组化分析，发现GPR182在多种肿瘤的血管内皮细胞中高表达，并可能通过调节趋化因子信号影响免疫细胞浸润，提示其作为肿瘤微环境调控的潜在靶点。
2. **文献名称**：*GPR182 regulates endothelial cell migration and angiogenesis through interaction with β-arrestin2*
**作者**：Chen B, et al.
**摘要**：研究通过GPR182抗体阻断实验，揭示GPR182与β-arrestin2的相互作用机制，表明其在血管内皮细胞迁移和病理性血管生成中的关键作用，为抗血管治疗提供新方向。
3. **文献名称**：*Expression profiling of orphan G-protein-coupled receptor GPR182 in inflammatory bowel disease*
**作者**：Wang Y, et al.
**摘要**：利用GPR182抗体检测炎症性肠病模型中的蛋白表达，发现GPR182在肠道内皮细胞中显著上调，可能通过调控血管通透性和炎症反应参与疾病进展。
(注：以上内容为示例性概括，实际文献需通过学术数据库检索确认。)
**Background of GPR182 Antibody**
GPR182. a class A G protein-coupled receptor (GPCR), remains an orphan receptor with an unidentified endogenous ligand. It is broadly expressed in endothelial and immune cells, as well as in various tissues, including the liver, intestine, and brain. Research suggests its involvement in angiogenesis, immune regulation, and tumor microenvironment modulation. GPR182 has been linked to cancer progression, particularly in hepatocellular carcinoma, colorectal cancer, and pancreatic ductal adenocarcinoma, where it may influence cell proliferation, migration, and vascular remodeling.
The GPR182 antibody is a critical tool for detecting and localizing GPR182 in experimental models. It enables studies on receptor expression patterns, cellular localization, and functional mechanisms via techniques like immunohistochemistry (IHC), western blotting (WB), and immunofluorescence (IF). Both polyclonal and monoclonal antibodies have been developed, often targeting extracellular or intracellular epitopes to assess membrane-bound or internalized receptor forms.
Current research focuses on elucidating GPR182's signaling pathways, potential ligands, and therapeutic relevance. Its role in regulating chemokine-like functions and cross-talk with other GPCRs highlights its potential as a drug target for cancer or inflammatory diseases. However, the lack of definitive ligand information and pathway characterization underscores the need for further investigation, with GPR182 antibodies remaining indispensable for advancing these studies.
×
