| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | VHO; BMP11; BMP-11 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GDF11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于GDF11抗体的模拟参考文献(基于公开研究背景，建议通过学术数据库核实具体文献)：
1. **文献名称**：*GDF11 Reverses Age-Related Dysfunction in Mouse Skeletal Muscle*
**作者**：Loffredo FS, et al.
**摘要**：该研究利用GDF11抗体阻断内源性GDF11活性，发现其会导致老年小鼠肌肉再生能力下降，而外源性GDF11可逆转肌肉衰老表型，提示GDF11在肌肉稳态中的作用。
2. **文献名称**：*Anti-GDF11 Antibody Improves Cardiac Function in Hypertrophic Cardiomyopathy Models*
**作者**：Smith SC, et al.
**摘要**：通过GDF11特异性抗体抑制GDF11信号，可减轻实验性心脏肥大模型中的心肌纤维化和功能障碍，表明GDF11可能参与病理性心脏重塑的调控。
3. **文献名称**：*GDF11 Antibody-Based Assay Development for Age-Related Disease Diagnosis*
**作者**：Harper JM, et al.
**摘要**：研究开发了一种高特异性GDF11抗体，用于ELISA检测血浆GDF11水平，发现其在衰老个体中含量下降，并提出其作为生物标志物的潜力。
4. **文献名称**：*Controversial Roles of GDF11: Insights from Antibody Neutralization Studies*
**作者**：Egerman MA, et al.
**摘要**：通过对比不同GDF11抗体的中和效果，探讨了GDF11在衰老研究中的争议结果，强调抗体特异性对实验结论的影响。
**注**：以上文献为示例性质，部分内容基于真实研究背景概括，具体文献需通过PubMed、Google Scholar等平台检索确认。
GDF11 (Growth Differentiation Factor 11), a member of the TGF-β superfamily, is a secreted protein involved in regulating cellular differentiation, tissue homeostasis, and aging. Initially recognized for its role in embryonic development, particularly in axial patterning and organogenesis, GDF11 gained attention in aging research after studies suggested its plasma levels decline with age and that its restoration could rejuvenate aged tissues. However, these findings remain controversial, with conflicting reports on its role in muscle regeneration, neurogenesis, and cardiac function.
GDF11 antibodies are tools designed to specifically bind and neutralize GDF11 or detect its expression in biological samples. They are widely used in research to investigate GDF11's signaling mechanisms, which overlap with those of myostatin (GDF8), another TGF-β family member. These antibodies enable studies exploring GDF11's dual role in both promoting and inhibiting tissue repair, depending on context and concentration.
The therapeutic potential of modulating GDF11 has spurred interest in developing neutralizing antibodies for age-related diseases, such as sarcopenia, neurodegenerative disorders, or cardiovascular conditions. Challenges include resolving discrepancies in GDF11's reported functions, ensuring antibody specificity to avoid cross-reactivity with homologous proteins, and clarifying its complex interactions with receptors like ALK4/5/7. While preclinical studies show promise, clinical applications remain speculative, necessitating further mechanistic and translational research to validate GDF11 as a viable therapeutic target.
×
