Rabbit Polyclonal CARD6 Antibody

The CARD6 (Caspase Activation and Recruitment Domain 6) antibody is a tool used to study the CARD6 protein, a member of the CARD family involved in innate immunity and apoptosis regulation. CARD6 contains a characteristic N-terminal CARD domain, which mediates protein-protein interactions, and a C-terminal coiled-coil domain. It is structurally related to other NOD-like receptor (NLR) family members but lacks a nucleotide-binding domain. Functionally, CARD6 has been implicated in modulating NF-κB and MAPK signaling pathways, potentially through interactions with proteins like BCL10 or RIPK2. though its exact mechanisms remain debated. Some studies suggest pro-inflammatory roles, while others indicate inhibitory effects, possibly context-dependent. Research on CARD6 is limited compared to other CARD proteins (e.g., CARD9 or CARD11), and its physiological relevance in humans remains unclear. However, it has been loosely associated with inflammatory diseases, cancer progression, and autoimmune disorders in preclinical models. CARD6 antibodies are primarily used in Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization (e.g., cytoplasmic distribution), and interaction networks. These studies aim to clarify its role in immune regulation and disease pathogenesis. Further validation of CARD6-specific antibodies is critical due to potential cross-reactivity with homologous CARD-containing proteins.