| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CD; ACUG; BLAU; IBD1; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human NOD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于NOD2抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用需通过学术数据库核实)：
---
1. **文献名称**：*NOD2-Specific Monoclonal Antibodies Reveal Differential Expression in Crohn's Disease Tissues*
**作者**：Smith A, et al.
**摘要**：该研究开发了针对NOD2蛋白的单克隆抗体，用于检测克罗恩病患者肠道组织中的NOD2表达水平，发现突变型NOD2的表达与炎症严重程度相关，为疾病诊断提供了潜在工具。
2. **文献名称**：*Structural Insights into NOD2 Activation Using Conformation-Specific Antibodies*
**作者**：Lee J, et al.
**摘要**：通过开发构象特异性抗体，揭示了NOD2在结合muramyl dipeptide(MDP)后的结构变化，阐明了其激活机制及突变导致功能异常的分子基础。
3. **文献名称**：*Therapeutic Targeting of NOD2 with Neutralizing Antibodies Attenuates Experimental Colitis*
**作者**：Zhang Y, et al.
**摘要**：研究证明中和性NOD2抗体可抑制过度激活的炎症信号通路，在小鼠结肠炎模型中显著减轻肠道损伤，提示其作为炎症性肠病治疗策略的潜力。
---
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“NOD2 antibody”、“anti-NOD2 therapeutics”等获取最新研究。
NOD2 (nucleotide-binding oligomerization domain-containing protein 2), also known as NLRC2. is a cytosolic pattern recognition receptor critical in innate immune responses. It detects bacterial peptidoglycan components, particularly muramyl dipeptide (MDP), and activates downstream signaling pathways like NF-κB and MAPK to trigger inflammatory responses. Structurally, NOD2 contains two N-terminal caspase recruitment domains (CARDs), a central NACHT domain for oligomerization, and C-terminal leucine-rich repeats (LRRs) responsible for ligand sensing.
NOD2 is highly expressed in immune cells (e.g., macrophages, dendritic cells) and epithelial cells, notably in the gastrointestinal tract. Genetic mutations in *NOD2* (e.g., frameshift, missense variants) are strongly linked to Crohn’s disease, Blau syndrome, and other autoinflammatory disorders. These mutations often impair MDP recognition or disrupt protein function, leading to dysregulated immune activation or defective bacterial clearance.
NOD2 antibodies are essential tools for studying its expression, localization, and signaling mechanisms. They enable detection of NOD2 in Western blotting, immunohistochemistry, and flow cytometry, aiding research on its role in inflammation, infection, and autoimmune diseases. Some antibodies target specific domains (e.g., LRR, CARD) to investigate functional or structural abnormalities caused by mutations. Additionally, NOD2 antibodies have potential diagnostic applications, helping identify aberrant expression in clinical samples, and may guide therapeutic strategies targeting NOD2-associated pathways in inflammatory bowel disease or cancer.
×
