| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | AIM; API6; PRO229; Spalpha; SP-ALPHA |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CD5L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CD5L抗体的示例性参考文献(注：内容为模拟示例，非真实文献)：
1. **标题**：*CD5L Antibody Attenuates Liver Fibrosis via Modulating Macrophage Polarization*
**作者**：Zhang Y, et al.
**摘要**：研究利用抗CD5L抗体在小鼠肝纤维化模型中干预，发现其通过抑制促炎性巨噬细胞活化，促进M2型极化，显著减少胶原沉积，提示CD5L抗体在纤维化疾病中的治疗潜力。
2. **标题**：*Therapeutic Targeting of CD5L in Rheumatoid Arthritis with Humanized Monoclonal Antibodies*
**作者**：Smith J, et al.
**摘要**：开发人源化抗CD5L单克隆抗体，在类风湿性关节炎模型中验证其疗效，结果显示抗体通过阻断CD5L与凋亡细胞结合，降低炎症因子水平并缓解关节损伤。
3. **标题**：*CD5L as a Biomarker in Metabolic Syndrome: Insights from Antibody-Based Detection*
**作者**：Lee H, et al.
**摘要**：通过抗CD5L抗体检测血浆CD5L水平，发现其与肥胖患者的胰岛素抵抗和脂肪组织炎症呈正相关，提示CD5L可作为代谢综合征的潜在生物标志物。
4. **标题**：*Structural Basis of CD5L Recognition by Neutralizing Antibodies in Atherosclerosis*
**作者**：Garcia-Ruiz C, et al.
**摘要**：解析CD5L蛋白与中和抗体的复合物结构，揭示抗体通过阻断CD5L与氧化低密度脂蛋白结合，抑制动脉粥样硬化斑块形成，为抗体药物开发提供依据。
(注：以上文献信息为模拟生成，实际引用时需以真实数据库检索结果为准。)
CD5L (CD5 Antigen-Like), also known as APRIL or CD5L, is a secreted glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily. Primarily expressed in immune cells like macrophages, dendritic cells, and specific lymphocyte subsets, it plays regulatory roles in inflammation, apoptosis, and lipid metabolism. Its structure includes conserved SRCR domains that mediate interactions with cell surface receptors such as CD5 and TLT-1. influencing immune signaling pathways.
CD5L antibodies are critical tools for studying its dual roles in disease contexts. In autoimmune disorders (e.g., rheumatoid arthritis), CD5L may suppress excessive inflammation by modulating macrophage activity. Conversely, in chronic infections or cancers, it might promote immune evasion by altering cytokine profiles in the tumor microenvironment. Its involvement in lipid homeostasis also links CD5L to metabolic diseases; elevated levels correlate with atherosclerosis progression through lipid-laden macrophage formation.
Research applications of CD5L antibodies include immunohistochemistry, flow cytometry, and functional blocking assays to dissect its mechanisms. Therapeutic potential is being explored, with antibody-based strategies aiming to either neutralize CD5L in pro-inflammatory conditions or enhance its activity in metabolic syndromes. Despite progress, its context-dependent functions require careful targeting to avoid paradoxical effects. Ongoing studies focus on tissue-specific expression patterns and receptor cross-talk to refine clinical applications.
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