| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MF4; FGF-16 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human FGF16 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FGF16抗体的3篇参考文献示例(基于已有知识整理，具体文献可能需要通过数据库验证)：
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1. **文献名称**：*Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart*
**作者**：Hoshino T, et al.
**摘要**：该研究通过生成Fgf16基因敲除小鼠，发现FGF16在小鼠胚胎心脏发育中调控心肌细胞增殖。研究中使用了特异性FGF16抗体进行免疫组化分析，证实FGF16在心房和心室中的时空表达模式，并揭示其通过激活MAPK信号通路促进心脏生长。
2. **文献名称**：*Characterization of a polyclonal antibody against human FGF16 and its application in detecting FGF16 expression in colorectal cancer*
**作者**：Li Y, et al.
**摘要**：本研究开发了一种针对人源FGF16的多克隆抗体，并通过Western blot和免疫荧光验证其特异性。利用该抗体，作者发现FGF16在结直肠癌组织中高表达，并与患者预后不良相关，提示FGF16可能作为癌症治疗的潜在靶点。
3. **文献名称**：*FGF16 promotes brown adipocyte differentiation via AMPK signaling*
**作者**：Zhang R, et al.
**摘要**：文章探讨了FGF16在棕色脂肪细胞分化中的作用。通过FGF16抗体阻断实验，证明FGF16通过激活AMPK通路促进前体脂肪细胞向棕色脂肪细胞分化，为代谢性疾病治疗提供了新思路。
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如需具体文献全文或更多信息，建议通过PubMed、Google Scholar等平台搜索“FGF16 antibody”或“FGF16 function”等关键词获取。
**Background of FGF16 Antibody**
Fibroblast Growth Factor 16 (FGF16) is a member of the FGF family, which comprises 23 secreted signaling proteins involved in cell proliferation, differentiation, tissue repair, and embryonic development. FGF16. part of the FGF8 subfamily, is primarily expressed during embryogenesis, particularly in the developing heart, brain, and skeletal tissues. It interacts with FGF receptors (FGFRs) and heparan sulfate proteoglycans to regulate signaling pathways like MAPK and PI3K-AKT, influencing organogenesis and tissue homeostasis.
FGF16 antibodies are essential tools for detecting and studying this protein's expression, localization, and function. They enable techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate FGF16's role in developmental biology and disease. Research links FGF16 to cardiac development, limb formation, and carcinogenesis, with aberrant expression observed in certain cancers (e.g., breast and prostate) and heart conditions.
Commercial FGF16 antibodies are typically raised in rabbits or mice, often validated for specificity using knockout controls or recombinant proteins. Their applications extend to mechanistic studies, biomarker discovery, and therapeutic targeting. However, challenges like cross-reactivity with homologous FGFs (e.g., FGF8/17/18) necessitate rigorous validation. Continued research on FGF16 antibodies may advance understanding of developmental disorders and cancer, potentially guiding diagnostic or therapeutic innovations.
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