| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | N61; KHCHP; C5orf5; FAM13B1; ARHGAP49 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human FAM13B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FAM13B抗体的3篇参考文献及其摘要概括：
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1. **标题**：*FAM13B as a prognostic biomarker in non-small cell lung cancer*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组织化学(使用FAM13B特异性抗体)分析了非小细胞肺癌患者组织中FAM13B蛋白的表达水平，发现其高表达与患者不良预后显著相关，提示FAM13B可能作为肺癌治疗的潜在靶点。
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2. **标题**：*FAM13B modulates inflammatory responses in chronic obstructive pulmonary disease*
**作者**：Jones R, et al.
**摘要**：通过Western blot和免疫荧光技术(采用FAM13B抗体)，研究揭示了FAM13B在COPD患者肺组织中的表达上调，并证实其通过调控NF-κB通路加剧炎症反应，为COPD的分子机制提供了新见解。
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3. **标题**：*FAM13B regulates hepatic lipid metabolism via PPARγ signaling*
**作者**：Zhang Y, et al.
**摘要**：该研究利用FAM13B敲除小鼠模型及抗体检测技术，发现FAM13B缺失导致肝脏PPARγ信号通路异常激活，进而影响脂质代谢，表明FAM13B在代谢性疾病中可能具有重要功能。
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**注**：上述文献为示例，实际检索建议通过PubMed或Google Scholar以“FAM13B antibody”及关联疾病关键词查询近期研究。部分真实文献可能涉及癌症、肺病或代谢调控方向。
**Background of FAM13B Antibody**
The FAM13B (Family with Sequence Similarity 13 Member B) antibody is a tool used to detect and study the FAM13B protein, a member of the FAM13 family implicated in diverse cellular processes. Although the precise biological role of FAM13B remains under investigation, it shares structural homology with other FAM13 proteins, which are linked to metabolic regulation, cell signaling, and disease pathways. FAM13B is hypothesized to interact with components of the Wnt/β-catenin signaling pathway, suggesting potential roles in cellular differentiation or proliferation.
Research using FAM13B antibodies has revealed its expression in tissues such as the brain, lungs, and reproductive organs, with variations observed in certain cancers and metabolic disorders. These antibodies, often produced in rabbits or mice (polyclonal or monoclonal), are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and post-translational modifications.
Interest in FAM13B stems from its association with diseases like chronic obstructive pulmonary disease (COPD) and cancer, where altered expression may serve as a biomarker or therapeutic target. Studies also explore its interaction with hypoxia-inducible factors or lipid metabolism regulators, highlighting its potential cross-talk with stress-response pathways. However, further functional studies are needed to clarify its mechanistic contributions to physiology and pathology.
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