| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | GMK |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human GUK1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GUK1抗体的3篇参考文献示例(内容基于假设性研究，实际文献需通过学术数据库验证)：
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1. **文献名称**: *"Development of a Monoclonal Antibody Specific for Human Guanylate Kinase 1 (GUK1) and Its Application in Neuroblastoma Studies"*
**作者**: Lee, J. et al.
**摘要**: 该研究报道了一种新型GUK1单克隆抗体的开发，通过免疫印迹和免疫荧光验证其特异性。实验表明，GUK1在神经母细胞瘤中高表达，可能参与肿瘤细胞增殖调控。
2. **文献名称**: *"GUK1 Interacts with Postsynaptic Density Proteins and Regulates Synaptic Plasticity in Mouse Models"*
**作者**: Smith, A.R. & Patel, T.
**摘要**: 利用GUK1抗体进行免疫共沉淀和脑组织免疫组化，发现GUK1与突触后致密区蛋白(如PSD-95)存在相互作用，提示其在突触可塑性和神经系统疾病中的潜在作用。
3. **文献名称**: *"Proteomic Analysis of GUK1 in Colorectal Cancer: Antibody-Based Detection and Clinical Implications"*
**作者**: Zhang, Y. et al.
**摘要**: 研究通过GUK1抗体对结直肠癌组织进行蛋白质组学分析，发现GUK1表达与肿瘤转移和患者预后显著相关，可能作为潜在生物标志物。
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**提示**：实际文献建议通过PubMed或Google Scholar以关键词“GUK1 antibody”或“Guanylate kinase 1 antibody”检索，并关注抗体开发、验证或功能研究的文章。
The guanylate kinase 1 (GUK1) antibody is a tool used to detect and study GUK1. a conserved enzyme critical for nucleotide metabolism. GUK1 catalyzes the ATP-dependent phosphorylation of GMP to GDP, a rate-limiting step in the cGMP-dependent signaling pathway and nucleotide synthesis. It plays a vital role in RNA/DNA biosynthesis, cell cycle regulation, and mitochondrial function. GUK1 is ubiquitously expressed, localized in the cytoplasm and mitochondria, and encoded by the *GUK1* gene in humans.
GUK1 antibodies are widely utilized in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate GUK1's expression, localization, and interactions in cellular models or tissues. Research highlights its involvement in diseases, including cancers (e.g., colorectal, hepatocellular carcinoma) where dysregulated GUK1 correlates with proliferation, and neurological disorders linked to mitochondrial dysfunction. Additionally, GUK1 interacts with proteins like postsynaptic density components, suggesting roles in neurodevelopment.
These antibodies aid in exploring GUK1’s molecular mechanisms, therapeutic potential, and biomarker utility. Validation for specificity, cross-reactivity, and application compatibility is essential for experimental accuracy. Ongoing studies focus on its dual metabolic and structural roles, particularly in cellular energy balance and disease pathogenesis.
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