Rabbit Polyclonal ID2 Antibody

The ID2 (Inhibitor of DNA Binding 2) antibody is a tool used to detect and study the ID2 protein, a member of the ID family of helix-loop-helix (HLH) transcriptional regulators. ID proteins lack the DNA-binding domain found in canonical HLH transcription factors, allowing them to act as dominant-negative inhibitors by sequestering basic HLH (bHLH) partners, thereby modulating gene expression. ID2 plays critical roles in cellular processes such as differentiation, proliferation, and apoptosis. It is particularly important in development, including neurogenesis, lymphangiogenesis, and T-cell development. Dysregulation of ID2 has been implicated in cancer, where it can exhibit dual roles—acting as either an oncogene or tumor suppressor depending on context. For example, ID2 overexpression is linked to tumor progression in certain cancers (e.g., breast, prostate), while its loss may drive aggressiveness in others (e.g., glioblastoma). The ID2 antibody is widely employed in research applications like Western blotting, immunohistochemistry, and flow cytometry to assess ID2 expression patterns in tissues or cell lines. Its utility extends to exploring ID2's involvement in stem cell maintenance, immune regulation, and therapeutic resistance, making it a valuable reagent in both basic and translational biomedical studies.