| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | IFN-alphaO |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human IFNA16 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IFNA16抗体的参考文献示例(注：以下为模拟虚构内容，实际文献需通过学术数据库查询)：
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1. **文献名称**：*Characterization of a Novel Monoclonal Antibody Specific for Human IFNA16*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种针对人IFNA16蛋白的单克隆抗体，验证了其在ELISA和Western Blot中的高特异性，并证实其可用于检测细胞因子分泌模型中的IFNA16表达。
2. **文献名称**：*IFNA16 Expression in Viral Infections: Role of Neutralizing Antibodies*
**作者**：Chen L, et al.
**摘要**：通过抗IFNA16多克隆抗体阻断实验，发现IFNA16在乙型肝炎病毒感染中通过调节干扰素信号通路发挥抗病毒作用，提示其作为治疗靶点的潜力。
3. **文献名称**：*Comparative Analysis of Interferon Alpha Subtype Antibodies in Autoimmune Diseases*
**作者**：Garcia R, et al.
**摘要**：比较了不同干扰素α亚型(包括IFNA16)抗体在系统性红斑狼疮患者血清中的水平，发现IFNA16自身抗体与疾病活动度呈显著相关性。
4. **文献名称**：*Development of a Sensitive Immunoassay for IFNA16 Detection*
**作者**：Wang Y, et al.
**摘要**：建立了一种基于单克隆抗体的高灵敏度夹心ELISA方法，用于定量检测血清中的IFNA16.为临床研究提供了可靠工具。
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建议通过PubMed、Web of Science等平台以“IFNA16 antibody”为关键词检索真实文献。
The IFNA16 antibody targets interferon alpha-16 (IFNA16), a member of the type I interferon (IFN) family, which plays critical roles in innate immunity. IFNA16 is part of the IFN-α subfamily, encoded by a cluster of genes on human chromosome 9p21.3. Type I IFNs, including IFN-α, are cytokines produced in response to viral infections, modulating immune responses through antiviral, immunoregulatory, and antiproliferative activities. IFNA16 specifically binds to the IFN-α/β receptor (IFNAR), activating the JAK-STAT signaling pathway to induce interferon-stimulated genes (ISGs) that inhibit viral replication and regulate immune cell functions.
Antibodies against IFNA16 are essential tools for studying its expression, localization, and interaction mechanisms. They are typically generated using recombinant IFNA16 proteins or synthetic peptides as immunogens in host species like rabbits or mice. These antibodies enable applications such as Western blotting, ELISA, immunohistochemistry, and flow cytometry to detect IFNA16 in biological samples. Cross-reactivity with other IFN-α subtypes must be validated due to high sequence homology. IFNA16-specific antibodies are particularly valuable in research on viral pathogenesis, autoimmune diseases, and cancer, where dysregulated IFN signaling is implicated. Recent studies also explore IFNA16's potential as a therapeutic target or biomarker, driving demand for high-specificity antibodies. Proper validation via knockout controls or neutralizing assays is critical to ensure antibody reliability in experimental models.
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