| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | Imp9 |
| WB Predicted band size | 116 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human IPO9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IPO9抗体的3篇参考文献示例(注：文献为模拟示例，实际文献请通过学术数据库查询)：
1. **文献名称**: "Characterization of IPO9 as a nuclear import factor for viral capsid proteins"
**作者**: Zhang L, et al.
**摘要**: 本研究利用特异性IPO9抗体证实了IPO9蛋白在介导多种病毒衣壳蛋白入核转运中的关键作用，通过免疫共沉淀和RNA干扰实验揭示了其分子机制。
2. **文献名称**: "Development of a monoclonal antibody targeting human Importin-9 for cancer biomarker studies"
**作者**: Tanaka K, et al.
**摘要**: 文章报道了一种新型IPO9单克隆抗体的开发，验证了其在免疫组化中的应用，并发现IPO9在乳腺癌组织中的高表达与患者预后不良相关。
3. **文献名称**: "Dynamic subcellular localization of IPO9 during cell cycle progression"
**作者**: Müller S, et al.
**摘要**: 通过IPO9抗体的免疫荧光染色，揭示了该蛋白在有丝分裂期间的动态定位变化，提示其可能参与染色体分离过程的调控。
如需具体文献，建议在PubMed或Web of Science中搜索关键词“IPO9 antibody”或“Importin-9 antibody”，筛选涉及抗体应用(如Western Blot、IF/IHC等)的研究论文。
The IPO9 antibody targets Importin-9 (IPO9), a member of the importin-β family of nuclear transport receptors. IPO9 facilitates the transport of proteins and RNA molecules between the cytoplasm and nucleus by binding cargoes through specific recognition signals, such as nuclear localization sequences (NLS). Unlike classical importins, IPO9 functions independently of importin-α, enabling direct interaction with cargoes like ribosomal proteins, histones, and certain viral components. This unique transport mechanism is critical for cellular processes, including ribosome biogenesis, chromatin assembly, and gene regulation.
Research on IPO9 has highlighted its role in cancer progression, viral infections, and developmental biology. Dysregulation of IPO9-mediated transport is linked to tumorigenesis, as it influences the nuclear import of oncoproteins or tumor suppressors. Additionally, IPO9 interacts with viral proteins to aid pathogen replication, making it a potential therapeutic target. Antibodies against IPO9 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interactions in cellular models or clinical samples. These tools have advanced understanding of IPO9's functional diversity and its implications in disease pathways.
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