| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | Imp7; RANBP7 |
| WB Predicted band size | 120 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human IPO7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与IPO7抗体相关的文献示例(注：文献信息为模拟生成，仅供参考)：
1. **《Importin-7 mediates nuclear transport of the mRNA export factor ALY/REF》**
- 作者：M. Köhler et al.
- 摘要：研究通过免疫沉淀和Western blot分析，验证IPO7在mRNA出核运输中的作用，使用特异性IPO7抗体证实其与ALY/REF蛋白的相互作用。
2. **《Role of Importin-7 in viral infection pathways》**
- 作者：T. Suzuki & R. Yanagi
- 摘要：通过免疫荧光和siRNA敲减实验，发现IPO7在乙型肝炎病毒(HBV)核衣壳入核过程中起关键作用，研究依赖IPO7抗体定位其亚细胞分布。
3. **《IPO7 expression correlates with colorectal cancer progression》**
- 作者：L. Wang et al.
- 摘要：利用免疫组化技术分析IPO7在结直肠癌组织中的表达水平，发现其高表达与患者预后不良相关，研究采用商业化IPO7抗体进行组织染色。
注：实际文献需通过PubMed、Google Scholar等平台以关键词“IPO7 antibody”或“Importin-7”检索。部分经典研究可能涉及抗体应用(如Cell或Nature子刊论文)，建议结合具体研究场景筛选。
The IPO7 antibody is designed to target Importin-7 (IPO7), a member of the Importin β family of nuclear transport receptors. IPO7 facilitates the transport of proteins and RNA molecules between the cytoplasm and nucleus by recognizing specific cargoes, including those with nuclear localization signals (NLS). It plays a critical role in cellular processes such as gene expression regulation, signal transduction, and cell cycle progression. IPO7 is also implicated in the nuclear import of ribosomal proteins and certain viral components, highlighting its diverse functional roles.
Research on IPO7 antibodies has expanded due to their utility in studying subcellular localization, protein interactions, and nucleocytoplasmic transport mechanisms. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect IPO7 expression in various tissues and cell types. Dysregulation of IPO7 has been linked to diseases such as cancer, where altered nuclear transport may contribute to tumor progression or drug resistance. Additionally, IPO7's interaction with viral pathogens, including HIV-1. underscores its relevance in virology and host-pathogen interactions.
The development and validation of IPO7-specific antibodies have enabled deeper insights into its structural and functional dynamics, aiding both basic research and potential therapeutic targeting. Commercial antibodies are typically raised in hosts like rabbits or mice, with validated specificity for human, mouse, or rat IPO7 isoforms.
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