Rabbit Polyclonal MAPKAPK2 Antibody

The MAPKAPK2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2) antibody is a key tool for studying the p38 MAPK signaling pathway, which regulates cellular responses to stress, inflammation, and cytokines. MAPKAPK2. a serine/threonine kinase, is directly phosphorylated and activated by p38 MAPK under conditions such as osmotic shock, UV radiation, or inflammatory stimuli. It mediates downstream effects by phosphorylating substrates involved in mRNA stability (e.g., HSP27. TTP) and cytokine production, linking extracellular signals to transcriptional and post-transcriptional regulation. Antibodies targeting MAPKAPK2 enable researchers to detect its expression, activation status (via phosphorylation at Thr334), and subcellular localization in various experimental models. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore its role in diseases such as cancer, autoimmune disorders, and neurodegenerative conditions. Validation of MAPKAPK2 antibodies often includes knockout cell lines or siRNA knockdown to confirm specificity. As dysregulation of the p38/MAPKAPK2 axis is implicated in chronic inflammation and tumor progression, such reagents are critical for elucidating mechanisms and evaluating therapeutic targets.