Rabbit Polyclonal SLC22A12 Antibody

The SLC22A12 antibody is a crucial tool for studying the URAT1 (urate transporter 1) protein encoded by the SLC22A12 gene. URAT1. primarily expressed in the apical membrane of renal proximal tubule cells, regulates uric acid reabsorption and maintains serum urate homeostasis. Dysregulation of URAT1 is linked to hyperuricemia, gout, and kidney stones, making it a therapeutic target for conditions like hereditary renal hypouricemia or hyperuricemia. The SLC22A12 antibody enables the detection, localization, and quantification of URAT1 in tissues or cell models, aiding research on its physiological roles, expression patterns, and interactions with drugs (e.g., uricosuric agents like lesinurad). It also supports clinical investigations into mutations or polymorphisms affecting URAT1 function. Developed through immunization with specific URAT1 epitopes, the antibody’s specificity is validated via Western blot, immunohistochemistry, or knockout controls. Its applications span mechanistic studies of urate transport, drug development for gout management, and diagnostic assays for renal urate-handling disorders. By facilitating URAT1 research, this antibody contributes to understanding metabolic disorders and advancing precision medicine approaches for urate-related diseases.