Rabbit Polyclonal HCRT Antibody

Hypocretin (HCRT), also known as orexin, is a neuropeptide produced in the hypothalamus, primarily involved in regulating sleep-wake cycles, appetite, and energy homeostasis. HCRT antibodies refer to antibodies targeting these peptides or their receptors, often studied in the context of neurological and autoimmune disorders. The most notable association is with narcolepsy type 1 (NT1), where a loss of HCRT-producing neurons leads to cerebrospinal fluid (CSF) hypocretin deficiency. While NT1 is primarily linked to genetic and environmental factors, autoimmune mechanisms are hypothesized to drive neuronal destruction. HCRT antibodies have been investigated as potential biomarkers, though their role remains controversial. Some studies detect autoantibodies against HCRT or its receptors in NT1 patients, suggesting an autoimmune etiology, while others fail to replicate these findings, indicating methodological variability or multifactorial pathology. Beyond narcolepsy, HCRT antibodies are explored in other conditions, including encephalitis and psychiatric disorders, though evidence is limited. Research tools, such as HCRT-specific antibodies, are also critical in neuroscience to map hypocretinergic pathways and study their functions. Overall, while HCRT antibodies hold diagnostic and mechanistic interest, their clinical significance and pathogenic role require further validation.