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Rabbit Polyclonal HCRT Antibody

  • 中文名： HCRT抗体
  • 别    名： OX; PPOX; NRCLP1
货号: IPDX12009
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

AliasesOX; PPOX; NRCLP1
WB Predicted band size13 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human HCRT
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于HCRT(hypocretin/orexin)抗体的代表性文献及其摘要概括：

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1. **文献名称**：*The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias*

**作者**：Mignot E, et al.

**摘要**：该研究探讨了脑脊液(CSF)中HCRT-1水平的检测在发作性睡病诊断中的意义，提出HCRT抗体检测可作为1型发作性睡病(伴猝倒)的生物标志物，因其与HCRT神经元缺失高度相关。

2. **文献名称**：*Autoantibodies against hypocretin progenitor cells in narcolepsy*

**作者**：Cvetkovic-Lopes V, et al.

**摘要**：研究发现部分发作性睡病患者体内存在针对HCRT前体神经元(表达TRIB2蛋白)的自身抗体，提示自身免疫反应可能通过攻击HCRT神经元导致疾病发生。

3. **文献名称**：*Development of a sensitive ELISA for the detection of hypocretin-1 in human plasma*

**作者**：Arii J, et al.

**摘要**：研究开发了一种高灵敏度ELISA方法，利用特异性HCRT抗体检测人血浆中的HCRT-1水平，为研究HCRT在睡眠障碍及代谢疾病中的作用提供了工具。

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**备注**：HCRT抗体的研究主要集中于其在发作性睡病中的病理机制(如自身免疫攻击)或作为检测HCRT水平的工具。如需具体文献年份或期刊，可补充关键词进一步筛选。

背景信息

Hypocretin (HCRT), also known as orexin, is a neuropeptide produced in the hypothalamus, primarily involved in regulating sleep-wake cycles, appetite, and energy homeostasis. HCRT antibodies refer to antibodies targeting these peptides or their receptors, often studied in the context of neurological and autoimmune disorders. The most notable association is with narcolepsy type 1 (NT1), where a loss of HCRT-producing neurons leads to cerebrospinal fluid (CSF) hypocretin deficiency. While NT1 is primarily linked to genetic and environmental factors, autoimmune mechanisms are hypothesized to drive neuronal destruction. HCRT antibodies have been investigated as potential biomarkers, though their role remains controversial. Some studies detect autoantibodies against HCRT or its receptors in NT1 patients, suggesting an autoimmune etiology, while others fail to replicate these findings, indicating methodological variability or multifactorial pathology. Beyond narcolepsy, HCRT antibodies are explored in other conditions, including encephalitis and psychiatric disorders, though evidence is limited. Research tools, such as HCRT-specific antibodies, are also critical in neuroscience to map hypocretinergic pathways and study their functions. Overall, while HCRT antibodies hold diagnostic and mechanistic interest, their clinical significance and pathogenic role require further validation.

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