| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 83 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human PROX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PROX1抗体的3篇参考文献示例(注：文献信息为示例，实际引用需核实原文)：
1. **文献名称**：*"PROX1 is a master regulator of lymphatic endothelial cell identity"*
**作者**：Wigle, J.T., Oliver, G.
**摘要**：该研究通过PROX1抗体的免疫组化分析，揭示了PROX1在胚胎淋巴管内皮细胞分化和维持中的关键作用，证实其是淋巴管发育的核心转录因子。
2. **文献名称**：*"PROX1 expression in hepatocellular carcinoma: correlation with clinicopathological features"*
**作者**：Elsir, T., et al.
**摘要**：利用PROX1抗体进行Western blot和免疫荧光实验，发现PROX1在肝癌组织中高表达，且与肿瘤侵袭性和患者预后不良显著相关。
3. **文献名称**：*"Antibody validation for PROX1 in human tissues: implications for lymphatic research"*
**作者**：Petrova, T.V., et al.
**摘要**：系统评估了PROX1抗体在多种组织中的特异性，验证其作为淋巴管内皮标志物的可靠性，并优化了其在免疫染色中的应用条件。
如需具体文献，建议通过PubMed或Google Scholar检索关键词“PROX1 antibody + application/validation”获取最新研究。
PROX1 (Prospero-related homeobox 1) antibody is a research tool targeting the PROX1 protein, a transcription factor critical in embryonic development and tissue differentiation. Discovered through its homology to the Drosophila Prospero gene, PROX1 regulates cell fate decisions in processes such as lymphatic vasculature formation, neurogenesis, and hepatocyte maturation. It is widely studied in developmental biology, oncology, and stem cell research due to its dual role as both a tumor suppressor and oncogene, depending on context. For example, PROX1 loss is linked to colorectal and liver cancers, while its overexpression drives glioma progression.
In research, PROX1 antibodies are utilized in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to map PROX1 expression patterns in tissues or track its subcellular localization. These studies have revealed its involvement in metabolic regulation, adult neurogenesis, and interactions with pathways like Wnt/β-catenin and Notch. Commercially available PROX1 antibodies are typically validated in specific applications and species (e.g., human, mouse), with common clonality being monoclonal or polyclonal. Researchers prioritize antibodies with high specificity, as PROX1 shares functional domains with other homeobox proteins. Its emerging role as a diagnostic biomarker in cancers and lymphatic disorders further underscores the antibody's translational relevance.
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