Rabbit Polyclonal RAB8B Antibody

The RAB8B antibody is a key tool for studying the RAB8B protein, a member of the RAS-associated binding (RAB) GTPase family. RAB8B regulates intracellular vesicular trafficking, particularly in the secretory pathway, by cycling between active GTP-bound and inactive GDP-bound states. It localizes to the Golgi apparatus, recycling endosomes, and plasma membrane, facilitating cargo transport, membrane remodeling, and ciliogenesis. While closely related to RAB8A, RAB8B exhibits distinct expression patterns, with higher levels in secretory tissues (e.g., pancreas, liver) and specialized cells (e.g., polarized epithelial cells). Dysregulation of RAB8B is implicated in diseases such as cancer, neurological disorders, and ciliopathies. The antibody enables detection and localization of RAB8B in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Validated antibodies often undergo knockout/knockdown controls to confirm specificity. Commercially available antibodies include monoclonal and polyclonal variants, targeting specific epitopes or post-translational modifications. Researchers use these to explore RAB8B's roles in membrane trafficking dynamics, cell polarity, and disease mechanisms. Optimal performance depends on experimental conditions (e.g., fixation methods, tissue types), requiring protocol optimization for specific applications.