| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human IQCJ |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于模拟生成的关于IQCJ抗体的参考文献示例(请注意，实际文献可能需要进一步验证，建议通过学术数据库检索确认)：
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1. **文献名称**: *Characterization of IQCJ as a novel biomarker in glioblastoma using a specific polyclonal antibody*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种针对IQCJ蛋白的多克隆抗体，验证了其在胶质母细胞瘤组织中的特异性表达。通过免疫组化和Western blot分析，发现IQCJ在肿瘤细胞核中高表达，提示其可能参与肿瘤侵袭性调控。
2. **文献名称**: *IQCJ regulates neuronal development: Insights from antibody-based localization studies*
**作者**: Chen L, et al.
**摘要**: 利用抗IQCJ抗体进行小鼠脑部免疫荧光染色，揭示了IQCJ在海马体和皮层神经元中的亚细胞定位。研究表眀，IQCJ通过调控微管稳定性影响神经元突触形成，为神经发育障碍研究提供了新靶点。
3. **文献名称**: *Development and validation of a monoclonal IQCJ antibody for colorectal cancer diagnostics*
**作者**: Wang Y, et al.
**摘要**: 本文报道了一种高特异性的IQCJ单克隆抗体的制备，并通过ELISA和免疫印迹验证其灵敏度。临床样本分析显示，IQCJ在结直肠癌中显著上调，可能作为早期诊断的生物标志物。
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**注意事项**：
- 上述文献为模拟示例，实际研究中关于IQCJ抗体的公开文献可能较少，建议通过**PubMed**或**Google Scholar**以关键词“IQCJ antibody”或“IQCJ protein function”检索最新研究。
- 若检索结果不足，可考虑扩大范围至IQCJ基因的功能研究或相关通路文献，或确认基因/蛋白名称拼写(如是否为IQCA/J、IQCG等类似名称)。
The IQCJ antibody is a research tool targeting the IQ motif-containing protein J (IQCJ), also known as CFAP46. a member of the IQ motif protein family. These proteins are characterized by calcium-binding IQ domains that mediate interactions with calmodulin and other signaling molecules. IQCJ is primarily expressed in ciliated tissues, including the brain, testis, and respiratory epithelium, and is implicated in ciliary structure and function. Studies suggest its role in regulating ciliary motility and intracellular signaling pathways, particularly in neuronal and reproductive systems.
IQCJ antibodies are widely used in basic research to investigate ciliopathies, neurodevelopmental disorders, and infertility linked to ciliary dysfunction. They enable detection of IQCJ expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in localization studies and protein interaction analyses. Recent work has explored IQCJ's association with primary ciliary dyskinesia (PCD) and its potential as a biomarker for ciliary-related pathologies.
Despite its emerging significance, IQCJ's precise molecular mechanisms remain understudied. Current antibody development focuses on improving specificity to address cross-reactivity with homologous IQ domain proteins. These antibodies are critical for advancing understanding of cilia biology and developing therapeutic strategies for diseases tied to ciliary defects.
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