| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ATFB13; BRGDA5; GEFSP1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SCN1B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SCN1B抗体的3篇参考文献(基于公开信息模拟，非真实文献)：
1. **名称**: "SCN1B autoantibodies in autoimmune encephalitis: Clinical correlates and functional effects"
**作者**: Smith A, et al.
**摘要**: 研究发现SCN1B抗体与自身免疫性脑炎相关，通过阻断钠通道β1亚基功能，导致神经元兴奋性异常，临床表现为癫痫发作和认知障碍。
2. **名称**: "Structural characterization of SCN1B-specific monoclonal antibodies for channelopathy research"
**作者**: Lee J, et al.
**摘要**: 开发了高特异性SCN1B单克隆抗体，通过冷冻电镜解析其结合表位，为研究钠通道β1亚基的结构与功能提供了新工具。
3. **名称**: "SCN1B antibody as a potential biomarker in febrile seizures"
**作者**: Chen H, et al.
**摘要**: 在部分热性惊厥患儿血清中检测到SCN1B抗体，提示其可能通过干扰钠通道调节参与惊厥病理过程，或成潜在诊断标志物。
(注：以上文献为示例性内容，实际研究中请通过PubMed或学术数据库查询真实文献。)
The SCN1B antibody targets the β1 subunit encoded by the SCN1B gene, a critical regulatory component of voltage-gated sodium channels (VGSCs). These channels are essential for initiating and propagating action potentials in excitable cells, including neurons and cardiomyocytes. The β1 subunit, a type I transmembrane protein, modulates channel gating, cell surface expression, and interacts with cell adhesion molecules to influence electrical signaling. SCN1B mutations are linked to neurological disorders such as Dravet syndrome, epilepsy, and developmental delays, as well as cardiac conditions like Brugada syndrome.
SCN1B antibodies are widely used in research to study protein expression, localization, and functional roles in health and disease. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess β1 subunit distribution in tissues or cultured cells. Additionally, these antibodies help investigate disease mechanisms, such as how pathogenic variants alter sodium channel kinetics or disrupt protein-protein interactions. Commercial SCN1B antibodies are typically raised in rabbits or mice, with validation across specific applications. Researchers also utilize them to explore therapeutic strategies targeting sodium channel dysfunction. Understanding SCN1B's role through antibody-based assays contributes to insights into channelopathies and potential treatment avenues.
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