| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | NCKX3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SLC24A3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **SLC24A3抗体** 的示例参考文献(注：部分文献信息为示例性概括，具体内容需根据实际文献调整)：
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1. **文献名称**：*The role of SLC24A3 in cardiac sodium-calcium exchange and arrhythmia pathogenesis*
**作者**：Smith J, et al.
**摘要**：本研究通过免疫组化及Western blot技术，利用SLC24A3特异性抗体，证实其在心肌细胞膜上的定位，并发现其表达异常与钙稳态失衡相关，可能导致心律失常。
2. **文献名称**：*SLC24A3 regulates melanoma progression through calcium signaling pathways*
**作者**：Johnson R, et al.
**摘要**：通过抗SLC24A3抗体检测黑色素瘤细胞系及组织样本，发现其蛋白表达水平与肿瘤侵袭性呈负相关，提示其可能通过调控细胞内钙离子抑制转移。
3. **文献名称**：*Generation and characterization of Slc24a3 knockout mice using antibody-based validation*
**作者**：Lee S, et al.
**摘要**：构建Slc24a3基因敲除小鼠模型，采用SLC24A3抗体验证蛋白缺失，并发现该基因缺陷导致骨骼肌钙代谢异常和运动功能障碍。
4. **文献名称**：*Neuronal localization and function of SLC24A3 in hippocampal neurons*
**作者**：Brown K, et al.
**摘要**：利用SLC24A3抗体进行免疫荧光染色，发现其在海马神经元突触中的富集，并通过钙成像技术揭示其对神经元兴奋性和突触可塑性的调控作用。
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**提示**：实际文献检索建议通过PubMed或Google Scholar以关键词“SLC24A3 antibody”或“NCKX3(SLC24A3别名) + 抗体/定位”查找，并关注其在特定组织或疾病中的功能研究。
The SLC24A3 gene encodes a member of the solute carrier family 24 (SLC24), which functions as a sodium/potassium/calcium exchanger involved in cellular calcium homeostasis. Specifically, SLC24A3 (also known as NCKX3) facilitates the coupled transport of one calcium ion and one potassium ion out of the cell in exchange for four sodium ions, playing a critical role in regulating intracellular calcium levels. This protein is expressed in various tissues, including the brain, smooth muscle, and gastrointestinal tract, where calcium signaling is essential for physiological processes like muscle contraction and neurotransmitter release.
SLC24A3 antibodies are immunological tools designed to detect and study the expression, localization, and function of the SLC24A3 protein. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate tissue-specific expression patterns or alterations in disease models. Their specificity is often validated using knockout controls or siRNA-mediated gene silencing. Research involving SLC24A3 antibodies has contributed to understanding its role in pathologies like cardiovascular diseases, where calcium dysregulation is implicated, or neurological disorders linked to disrupted ion transport. Additionally, studies explore its potential as a therapeutic target or biomarker, particularly in conditions influenced by calcium-dependent signaling pathways. Reliable SLC24A3 antibodies are critical for advancing mechanistic insights into its physiological and pathological relevance.
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