首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal SMC2 Antibody

  • 中文名: SMC2抗体
  • 别    名: CAPE; CAP-E; SMC-2; SMC2L1
货号: IPDX12215
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/10-1/50 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

AliasesCAPE; CAP-E; SMC-2; SMC2L1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human SMC2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

以下是关于SMC2抗体的3篇文献示例(注:文献信息为模拟生成,实际引用需核实原文):

1. **文献名称**:*SMC2 as a Novel Prognostic Biomarker in Pan-Cancer Analysis*

**作者**:Li et al. (2020)

**摘要**:通过免疫组化(使用SMC2抗体)分析SMC2在多种癌症组织中的表达,发现其高表达与肿瘤增殖、转移及患者不良预后显著相关,提示SMC2可能作为泛癌预后标志物。

2. **文献名称**:*Cohesin Subunit SMC2 Regulates Chromosome Stability in Mitosis*

**作者**:Smith et al. (2018)

**摘要**:利用SMC2抗体进行免疫荧光染色,发现SMC2缺失导致染色体分离异常和微核形成,证明其在维持有丝分裂中染色体结构完整性上的关键作用。

3. **文献名称**:*SMC2-Mediated Chromatin Remodeling in Stem Cell Differentiation*

**作者**:Wang et al. (2019)

**摘要**:通过Western blot(使用SMC2抗体)及ChIP-seq技术,揭示SMC2通过调控染色质三维构象影响干细胞多能性基因表达,推动定向分化进程。

4. **文献名称**:*Targeting SMC2 for Cancer Therapy: Insights from Antibody-Based Inhibition*

**作者**:Garcia-Rodriguez et al. (2021)

**摘要**:开发高特异性SMC2单克隆抗体,体外实验显示其可抑制肿瘤细胞增殖并诱导凋亡,为靶向黏连蛋白的抗癌策略提供实验依据。

(如需真实文献,建议通过PubMed/Google Scholar以“SMC2 antibody”或“SMC2 function”为关键词检索。)

背景信息

The SMC2 antibody is a crucial tool for studying the structural maintenance of chromosomes (SMC) protein family, specifically targeting the SMC2 subunit. SMC2. a core component of the condensin complex (condensin I and II), plays a vital role in chromosome organization and segregation during mitosis and meiosis. It partners with SMC4 to form a heterodimer that drives ATP-dependent chromatin compaction, ensuring proper sister chromatid resolution and genomic stability. Dysregulation of SMC2 is linked to chromosomal instability, aneuploidy, and cancer progression. Researchers use SMC2 antibodies in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate its expression, localization, and interactions in cell cycle regulation, DNA repair, and developmental biology. These antibodies are essential for exploring SMC2's functional roles in diseases, particularly cancers, where its overexpression correlates with poor prognosis. Commercial SMC2 antibodies are typically validated for specificity across human, mouse, and rat models, aiding translational studies. Ongoing research focuses on its potential as a therapeutic target and biomarker, emphasizing the antibody's utility in both basic and clinical contexts.

客户数据及评论

折叠内容

大包装询价

×