Rabbit Polyclonal SNX33 Antibody

The SNX33 antibody is a tool used to detect sorting nexin 33 (SNX33), a member of the sorting nexin family involved in intracellular membrane trafficking and protein sorting. SNX33 belongs to a group of proteins characterized by a phox homology (PX) domain, which binds phosphoinositides to facilitate membrane association. While less studied than other sorting nexins (e.g., SNX1 or SNX2), SNX33 is implicated in endosomal sorting, receptor recycling, and cellular signaling pathways. It interacts with components of the retromer complex, which mediates retrograde transport from endosomes to the Golgi apparatus. Research suggests SNX33 may regulate trafficking of specific cargo proteins, impacting processes like cytokine signaling or receptor degradation. The SNX33 antibody is typically used in techniques such as Western blotting, immunofluorescence, or immunoprecipitation to study its expression, localization, and molecular interactions. Its development aids in exploring SNX33's role in physiological contexts (e.g., immune response) or pathological conditions (e.g., cancer, neurodegenerative diseases). Validation of the antibody often includes testing for cross-reactivity with other SNX family members to ensure specificity.