Rabbit Polyclonal SNX3 Antibody

The SNX3 (Sorting Nexin 3) antibody is a tool used to detect and study the SNX3 protein, a member of the sorting nexin family involved in membrane trafficking and cellular signaling. SNX3 contains a Phox homology (PX) domain that binds phosphatidylinositol lipids, enabling its recruitment to endosomal membranes. It plays a key role in retromer-mediated cargo sorting, facilitating the recycling of transmembrane proteins (e.g., Wntless, cation-independent mannose 6-phosphate receptor) from endosomes to the trans-Golgi network or plasma membrane. SNX3 also regulates endosomal morphology and interacts with components of the retromer complex, such as VPS26 and VPS35. Dysregulation of SNX3 has been linked to neurodegenerative diseases, cancer, and metabolic disorders. Researchers use SNX3 antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and function in cellular pathways. These antibodies aid in elucidating SNX3's role in maintaining protein homeostasis, organelle dynamics, and disease mechanisms, making them valuable in both basic research and translational studies.