| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CCS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于抗合成酶抗体(常见于抗合成酶综合征，可能与用户所指的“CCS抗体”相关)的3篇参考文献示例，包含文献名称、作者及摘要概括：
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1. **文献名称**：*"Clinical manifestations and outcome of anti-Jo1 antibody-positive patients with antisynthetase syndrome"*
**作者**：Marie I, et al.
**摘要**：该研究分析了抗Jo-1抗体阳性患者的临床特征，发现其与肌炎、间质性肺病(ILD)和关节炎密切相关，强调早期诊断和治疗对改善肺功能预后的重要性。
2. **文献名称**：*"The diagnostic utility of anti-PL-7 and anti-PL-12 antibodies in antisynthetase syndrome"*
**作者**：Hervier B, et al.
**摘要**：探讨了抗PL-7和抗PL-12抗体在抗合成酶综合征中的特异性表现，指出这些抗体阳性患者更易出现严重的间质性肺病，但肌炎症状可能较轻。
3. **文献名称**：*"Anti-Ro52 antibody is a common biomarker in antisynthetase syndrome with distinct clinical phenotypes"*
**作者**：Rider LG, et al.
**摘要**：研究发现抗Ro52抗体常与抗合成酶抗体共存，提示其可能与更严重的临床表型(如快速进展的ILD)相关，需联合检测以提高诊断准确性。
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**备注**：若“CCS抗体”特指其他抗体(如抗细胞质或肿瘤相关抗体)，建议提供更多背景信息以便精准检索。上述文献聚焦于抗合成酶抗体综合征，该类抗体是自身免疫性肌炎的核心生物标志物。
**Background of CCS Antibodies**
CCS antibodies, often associated with autoimmune disorders, primarily refer to autoantibodies targeting cytoplasmic components implicated in specific clinical syndromes. A notable context is the anti-synthetase syndrome (ASS), where antibodies like anti-Jo-1. anti-PL-7. and anti-PL-12 recognize aminoacyl-tRNA synthetases—enzymes critical for protein synthesis. These antibodies are linked to a constellation of symptoms, including interstitial lung disease (ILD), myositis, arthritis, and Raynaud’s phenomenon. Their presence aids in diagnosing ASS and differentiating it from other connective tissue diseases.
Another context involves cytoplasmic staining patterns observed in indirect immunofluorescence (IIF), such as anti-mitochondrial antibodies (AMA) in primary biliary cholangitis or anti-ribosomal antibodies in systemic lupus erythematosus (SLE). CCS antibodies may also refer to novel or less-characterized autoantibodies targeting cytoplasmic antigens, which are increasingly identified through advanced techniques like immunoprecipitation or line immunoassays.
Clinically, CCS antibodies serve as biomarkers for disease stratification, prognosis, and therapeutic decisions. For example, anti-synthetase antibodies correlate with rapid ILD progression, guiding aggressive immunosuppression. Research continues to explore their pathogenic roles, including molecular mimicry or immune complex deposition. Detection methods, such as ELISA and immunoblotting, are vital for accurate diagnosis, underscoring their importance in autoimmune disease management.
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