| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SODD; BAG-4 |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human BAG4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BAG4抗体的3篇参考文献示例(注：文献信息为模拟概括，实际需通过学术数据库验证)：
1. **文献名称**: *BAG4/SODD interacts with TNF receptor 1 to regulate apoptotic signaling*
**作者**: Jiang, Y., et al.
**摘要**: 研究揭示了BAG4(又称SODD)通过与肿瘤坏死因子受体1(TNFR1)结合抑制细胞凋亡，利用BAG4抗体验证其蛋白表达，证明其在死亡受体信号通路中的调控作用。
2. **文献名称**: *Overexpression of BAG4 in gastric cancer and its correlation with poor prognosis*
**作者**: Zhang, L., et al.
**摘要**: 通过免疫组化实验(使用BAG4抗体)发现BAG4在胃癌组织中高表达，且与肿瘤分期、转移及患者生存率降低显著相关。
3. **文献名称**: *BAG4 promotes breast cancer progression by modulating HER2 stability*
**作者**: Chen, X., et al.
**摘要**: 研究利用BAG4抗体进行Western blot分析，证实BAG4通过稳定HER2蛋白表达促进乳腺癌细胞增殖和耐药性，提示其作为潜在治疗靶点。
建议通过PubMed或Google Scholar以“BAG4 antibody”或“BAG4 function”为关键词检索最新文献获取准确信息。
The BAG4 antibody targets the BAG family molecular chaperone regulator 4 (BAG4), also known as SODD (Silencer of Death Domains), a protein involved in regulating apoptosis and stress responses. BAG4 belongs to the BAG protein family, characterized by their BAG domain, which interacts with heat shock protein 70 (HSP70) to modulate protein folding, degradation, and anti-apoptotic signaling. BAG4 specifically binds to death domains of tumor necrosis factor (TNF) receptor 1 (TNFR1) and related receptors, inhibiting apoptosis by blocking death domain-mediated signaling. It also interacts with Bcl-2. further promoting cell survival.
BAG4 is implicated in cancer progression, where its overexpression is linked to tumor growth, chemotherapy resistance, and poor prognosis in cancers such as breast and lung cancer. Additionally, BAG4 participates in NF-κB activation, inflammation, and endoplasmic reticulum (ER) stress responses. Antibodies against BAG4 are essential tools for studying its expression, localization, and functional roles via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Research on BAG4 antibodies may contribute to therapeutic strategies targeting apoptosis pathways or molecular chaperone networks in cancer and neurodegenerative diseases. However, its dual roles in pro-survival and stress adaptation require further exploration to clarify context-dependent mechanisms.
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