| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | Mieap; SPETEX1 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SPATA18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SPATA18抗体的模拟参考文献示例(实际文献需通过PubMed或Google Scholar检索确认)：
---
1. **文献名称**: *SPATA18 regulates mitochondrial clearance during cellular stress via selective autophagy*
**作者**: Hashimoto Y, et al.
**摘要**: 本研究利用SPATA18抗体，通过免疫印迹和免疫荧光技术，揭示了SPATA18在氧化应激条件下介导线粒体自噬的机制，证明其通过结合LC3促进受损线粒体的清除。
2. **文献名称**: *Developmental expression of SPATA18 in murine testis: Implications for spermatogenesis*
**作者**: Smith J, et al.
**摘要**: 通过免疫组化分析SPATA18抗体标记的小鼠睾丸组织，发现该蛋白在精子细胞发育晚期高表达，提示其在精子形成中可能参与染色质重塑或DNA修复。
3. **文献名称**: *Downregulation of SPATA18 in hepatocellular carcinoma correlates with poor prognosis*
**作者**: Chen L, et al.
**摘要**: 使用SPATA18抗体对肝癌组织进行免疫组化检测，发现其表达显著低于癌旁组织，且低表达与肿瘤转移和患者生存率降低相关，提示其潜在抑癌作用。
4. **文献名称**: *SPATA18 interacts with p53 to modulate oxidative stress-induced apoptosis*
**作者**: Yamamoto K, et al.
**摘要**: 通过Co-IP和抗体共定位实验，证实SPATA18与p53在氧化应激下的相互作用，调控线粒体凋亡通路，为神经退行性疾病研究提供新靶点。
---
**注意**：以上为模拟文献，实际研究中SPATA18抗体的应用可能有限，建议通过学术数据库结合关键词(如“SPATA18 antibody”、“mitochondrial autophagy”、“spermatogenesis”)检索最新成果。
The SPATA18 (spermatogenesis-associated 18) gene encodes a protein implicated in mitochondrial quality control and cellular stress responses. Also known as PGAM5-binding protein 1 (PGAM5P1), SPATA18 interacts with PGAM5. a phosphatase involved in mitochondrial dynamics and mitophagy. Studies suggest SPATA18 plays a role in eliminating damaged mitochondria by recruiting autophagy machinery, linking it to mitochondrial homeostasis and apoptosis regulation. Its expression is tissue-specific, with higher levels observed in testes, suggesting a potential role in spermatogenesis. Dysregulation of SPATA18 has been associated with male infertility, neurodegenerative disorders, and cancer, where mitochondrial dysfunction is a hallmark.
SPATA18 antibodies are critical tools for studying these processes, enabling detection and localization of the protein via techniques like Western blot, immunohistochemistry, and immunofluorescence. Researchers use these antibodies to explore SPATA18's involvement in stress-induced mitophagy, oxidative damage response, and its interactions with mitochondrial proteins. Commercial SPATA18 antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes with validated cross-reactivity in human, mouse, or rat samples. Recent studies also investigate SPATA18's potential as a biomarker for diseases linked to mitochondrial impairment or as a therapeutic target. However, variability in antibody specificity and the gene's relatively recent characterization necessitate careful validation in experimental models.
×
