| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NEAS; EIEE5; SPTA2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SPTAN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于 **SPTAN1抗体** 的模拟参考文献示例(基于领域内常见研究方向概括，非真实文献)：
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1. **文献名称**：*"SPTAN1 Cleavage in Traumatic Brain Injury: A Biomarker for Axonal Damage"*
**作者**：Johnson, R. et al. (2018)
**摘要**：研究通过Western blot和免疫荧光技术，利用SPTAN1抗体检测脑损伤模型中α-II血影蛋白的C末端裂解片段(SBDP150)，发现其与轴突损伤程度呈正相关，提示SPTAN1裂解可作为脑创伤的生物标志物。
2. **文献名称**：*"Spectrin Breakdown Products in Alzheimer’s Disease: Role of SPTAN1 Proteolysis"*
**作者**：Smith, A. et al. (2015)
**摘要**：分析阿尔茨海默病患者脑组织样本，使用SPTAN1抗体发现α-II血影蛋白异常降解，其裂解产物与淀粉样斑块沉积和神经元凋亡相关，表明SPTAN1异常可能参与神经退行性病变机制。
3. **文献名称**：*"SPTAN1 Deficiency Disrupts Neuronal Morphogenesis: Insights from CRISPR-Cas9 Knockout Models"*
**作者**：Chen, L. et al. (2019)
**摘要**：通过CRISPR-Cas9敲除SPTAN1.结合免疫组化(SPTAN1抗体)发现神经元细胞骨架紊乱，突触连接减少，证实SPTAN1对维持神经元形态和功能的关键作用。
4. **文献名称**：*"Overexpression of SPTAN1 in Glioblastoma and Its Prognostic Significance"*
**作者**：Lee, H. et al. (2020)
**摘要**：利用SPTAN1抗体对胶质母细胞瘤组织进行免疫组化分析，发现SPTAN1高表达与肿瘤侵袭性和患者生存期缩短相关，提示其可能作为潜在治疗靶点。
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**注**：以上为模拟文献，实际引用需查询具体数据库(如PubMed)。SPTAN1抗体常用于研究细胞骨架动态、神经损伤及癌症等领域。
The SPTAN1 antibody targets α-II spectrin, a large cytoskeletal protein encoded by the SPTAN1 gene. α-II spectrin is a critical component of the cell membrane-associated spectrin-actin network, primarily involved in maintaining structural integrity, cell shape, and mechanical flexibility in various tissues, particularly neurons. It forms heterodimers with β-spectrin subunits, stabilizing plasma membranes and facilitating interactions with intracellular proteins like ankyrin and actin. SPTAN1 is essential for axonal development, synaptic function, and cell division.
Antibodies against SPTAN1 are widely used in research to study its expression, localization, and role in neurological disorders. Mutations or dysregulation of SPTAN1 are linked to early infantile epileptic encephalopathy, spinocerebellar ataxia, and traumatic brain injury. In diagnostics, SPTAN1 antibodies help detect spectrin breakdown products in blood, serving as biomarkers for acute brain injury. Additionally, these antibodies aid in exploring cancer biology, as altered spectrin expression is observed in certain malignancies. Commercial SPTAN1 antibodies are validated for techniques like Western blot, immunohistochemistry, and immunofluorescence, making them vital tools for both basic and clinical research.
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