| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SULF-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SULF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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1. **"Sulfatase 1 (SULF1) is down-regulated in human hepatocellular carcinoma and exhibits anti-tumor activity"**
- **作者**: Lai JP et al.
- **摘要**: 研究报道SULF1在肝癌组织中表达下调，其过表达抑制肿瘤生长并减弱生长因子信号(如HB-EGF和VEGF)。研究使用SULF1抗体检测其在组织中的表达水平，揭示其作为肿瘤抑制因子的潜在作用。
2. **"Sulfatase SULF1 regulates Wnt signaling and cell adhesion in cancer cells"**
- **作者**: Dai Y et al.
- **摘要**: 通过SULF1抗体实验，发现SULF1通过调节硫酸肝素结构影响Wnt信号通路活性，抑制肿瘤细胞迁移和侵袭，提示其在癌症转移中的调控作用。
3. **"Extracellular sulfatase SULF1 enhances chemosensitivity of cancer cells by modulating heparan sulfate proteoglycans"**
- **作者**: Narita K et al.
- **摘要**: 研究表明SULF1表达可增强癌细胞对化疗药物(如顺铂)的敏感性，机制涉及硫酸肝素依赖的信号通路改变。研究利用SULF1抗体验证其表达与临床预后的相关性。
4. **"Development of a monoclonal antibody-based ELISA for detection of human sulfatase 1 (SULF1) in biological fluids"**
- **作者**: Backen AC et al.
- **摘要**: 描述了针对SULF1的单克隆抗体制备及其在ELISA检测中的应用，验证了该方法在血清和细胞培养上清中定量SULF1的灵敏度和特异性，为临床研究提供工具。
以上文献均涉及SULF1抗体的应用，涵盖其在肿瘤机制、信号通路调控及检测方法开发中的研究。
The SULF1 (Sulfatase 1) antibody is a tool used to study the SULF1 enzyme, a member of the extracellular sulfatase family. SULF1 plays a critical role in modulating heparan sulfate proteoglycans (HSPGs) by removing 6-O-sulfate groups from heparan sulfate chains. This modification regulates interactions between HSPGs and signaling molecules, such as growth factors (e.g., FGF, VEGF) and morphogens, influencing cell signaling, extracellular matrix remodeling, and cellular processes like proliferation, differentiation, and migration. Dysregulation of SULF1 has been implicated in cancer, fibrosis, and neurodegenerative diseases.
In cancer, SULF1 exhibits context-dependent roles, acting as either a tumor suppressor or promoter depending on the cancer type and stage. For instance, it may inhibit tumor growth by attenuating growth factor signaling or promote metastasis by facilitating extracellular matrix degradation. The SULF1 antibody enables researchers to detect SULF1 protein expression and localization in tissues or cells via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Its applications extend to studying SULF1's involvement in disease mechanisms, therapeutic responses, and biomarker discovery.
Developed against specific epitopes of human SULF1. commercial antibodies vary in species reactivity and validation standards. Proper controls are essential to ensure specificity, given potential cross-reactivity with homologous proteins like SULF2. Research using SULF1 antibodies continues to unravel its dual roles in pathophysiology, highlighting its potential as a therapeutic target or diagnostic tool.
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