| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | hTh9 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human THAP9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是几篇假设的关于THAP9抗体的参考文献示例(实际文献需通过学术数据库验证)：
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1. **文献名称**：*THAP9 regulates pluripotency in embryonic stem cells through histone modification*
**作者**：Smith A, et al.
**摘要**：研究利用THAP9特异性抗体，发现THAP9通过调控组蛋白H3K4甲基化维持胚胎干细胞的自我更新能力，敲低THAP9导致多能性基因表达下降。
2. **文献名称**：*THAP9 antibody-based profiling reveals its overexpression in hepatocellular carcinoma*
**作者**：Zhang Y, et al.
**摘要**：通过THAP9抗体进行免疫组化分析，发现THAP9在肝癌组织中高表达，并与患者预后不良相关，提示其作为潜在肿瘤标志物的价值。
3. **文献名称**：*THAP9 interacts with LINE-1 retrotransposons via its zinc-finger domain*
**作者**：Lee J, et al.
**摘要**：研究利用THAP9抗体进行免疫共沉淀(Co-IP)，证实THAP9通过锌指结构域与LINE-1转座子结合，可能参与基因组稳定性调控。
4. **文献名称**：*Development of a novel monoclonal antibody against human THAP9 for neurodegenerative disease research*
**作者**：Garcia R, et al.
**摘要**：报道一种高特异性THAP9单克隆抗体的开发，验证其在Western blot和免疫荧光中的应用，并发现THAP9在阿尔茨海默病患者脑组织中异常聚集。
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建议通过PubMed、Google Scholar等平台，以关键词“THAP9 antibody”、“THAP9 function”检索最新文献。
The THAP9 antibody is designed to target the THAP domain-containing protein 9 (THAP9), a member of the THAP family of proteins characterized by a zinc-dependent DNA-binding domain. THAP9 is evolutionarily conserved and shares homology with the Hsmar1 transposase, suggesting potential roles in transcriptional regulation, chromatin remodeling, and mobilization of transposable elements. Studies indicate THAP9 may influence genomic stability, cell proliferation, and differentiation, with emerging links to cancer biology and neurological disorders. Its expression has been detected in various tissues, including the brain, testes, and certain tumors, though its precise physiological and pathological functions remain under investigation.
The THAP9 antibody is primarily used in research to detect and quantify THAP9 protein levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in elucidating THAP9’s interaction partners, subcellular localization, and regulatory mechanisms. Recent applications include exploring its involvement in DNA repair pathways, epigenetic modulation, and transposon silencing. Commercially available antibodies are typically validated for specificity and sensitivity, though batch variability can occur. As THAP9 gains attention for its dual roles in genome regulation and disease, this antibody serves as a critical tool for advancing studies in developmental biology, oncology, and neurobiology.
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