首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal TM9SF1 Antibody

  • 中文名: TM9SF1抗体
  • 别    名: MP70; HMP70
货号: IPDX12302
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesMP70; HMP70
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human TM9SF1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

由于我无法实时访问学术数据库或最新文献,以下示例为虚构的参考文献结构,仅供说明格式使用。建议通过PubMed、Google Scholar等平台检索真实文献:

---

**1. 文献名称**: *TM9SF1 regulates autophagosome formation through membrane trafficking in cancer cells*

**作者**: Zhang L, et al.

**摘要**: 本研究使用TM9SF1抗体(货号:ABX-123)进行Western blot和免疫荧光实验,证实TM9SF1通过调控自噬相关蛋白LC3-II的定位影响结直肠癌细胞的自噬过程。

---

**2. 文献名称**: *TM9SF1 as a novel biomarker for glioblastoma progression*

**作者**: Kim S, et al.

**摘要**: 通过TM9SF1特异性抗体(克隆号:3C7)的免疫组化分析,发现TM9SF1在胶质母细胞瘤组织中高表达,且与患者生存率负相关,提示其作为治疗靶点的潜力。

---

**3. 文献名称**: *TM9SF1 deficiency impairs lysosomal function and neuronal homeostasis*

**作者**: Müller R, et al.

**摘要**: 利用TM9SF1敲除小鼠模型及抗体(来源:Santa Cruz, sc-55500)进行共聚焦显微镜观察,揭示TM9SF1缺失导致溶酶体酸化和神经元内脂质沉积异常。

---

**实际检索建议**:

- 在PubMed中搜索关键词:`"TM9SF1" AND ("antibody" OR "immunohistochemistry")`

- 关注近5年《Cell Reports》《Journal of Cell Science》等期刊的相关研究。

如需具体文献协助,请提供更详细的研究背景或目标(如疾病模型、实验方法等)。

背景信息

The TM9SF1 (Transmembrane 9 Superfamily Member 1) antibody is a tool used to detect and study the TM9SF1 protein, a member of the conserved TM9SF family implicated in intracellular trafficking and membrane dynamics. TM9SF1 is a multi-pass transmembrane protein localized primarily in the Golgi apparatus and endosomes, where it regulates vesicular transport, lysosomal function, and autophagy. It interacts with components of the endosomal sorting complex and plays roles in maintaining organelle integrity, protein sorting, and cellular homeostasis. Dysregulation of TM9SF1 has been linked to pathologies, including cancer metastasis and neurodegenerative disorders. The TM9SF1 antibody, often developed in rabbit or mouse hosts using peptide immunogens, enables the detection of TM9SF1 expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Its applications span elucidating TM9SF1's involvement in membrane trafficking pathways, autophagy-lysosomal dysfunction, and disease mechanisms. Validation includes testing for specificity through knockdown/knockout controls. Research using this antibody contributes to understanding cellular trafficking networks and potential therapeutic targets in diseases associated with TM9SF1 aberrations.

客户数据及评论

折叠内容

大包装询价

×