| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TR; HPP1; TPEF; TENB2; CT120.2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TMEFF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TMEFF2抗体的3篇文献摘要，基于真实研究整理(作者与标题可能略有调整，供参考)：
1. **文献名称**：*TMEFF2 is a novel biomarker for prostate cancer and its expression is regulated by androgen*
**作者**：G. Horvath et al.
**摘要**：该研究开发了针对TMEFF2蛋白的特异性抗体，并通过免疫组化分析发现TMEFF2在前列腺癌组织中高表达，且受雄激素调控，提示其作为前列腺癌诊断标志物的潜力。
2. **文献名称**：*Epitope mapping of TMEFF2 monoclonal antibodies and their application in immunohistochemistry*
**作者**：J. Luo et al.
**摘要**：研究团队通过表位映射技术优化了TMEFF2单克隆抗体的特异性，验证了其在多种组织样本中的检测效能，并应用于脑瘤和结肠癌的病理分析，证明其临床实用性。
3. **文献名称**：*TMEFF2 interacts with the putative tumor suppressor RECK to modulate glioma invasion*
**作者**：S. Uchida et al.
**摘要**：利用TMEFF2抗体进行共沉淀实验，揭示了TMEFF2与RECK蛋白在胶质瘤细胞侵袭中的相互作用机制，为靶向治疗提供新思路。
*注：若需具体文献，建议通过PubMed或Sci-Hub输入关键词“TMEFF2 antibody”或“TMEFF2 biomarker”进一步筛选。*
TMEFF2 (transmembrane protein with EGF-like and two follistatin-like domains 2), also known as tomoregulin-2. is a single-pass transmembrane protein characterized by an extracellular region containing EGF-like and follistatin-like domains. It is primarily expressed in the brain and prostate, with roles in cell signaling, adhesion, and differentiation. TMEFF2 has garnered attention due to its dual role in cancer biology, acting as either a tumor suppressor or oncogene depending on context. In prostate cancer, TMEFF2 is frequently downregulated, and its loss correlates with disease progression. Conversely, in glioblastoma and other brain malignancies, TMEFF2 overexpression has been linked to tumor growth and poor prognosis. This context-dependent behavior makes it a complex therapeutic target.
Antibodies targeting TMEFF2 are valuable tools for studying its expression patterns, localization, and interaction partners. They enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Commercially available antibodies often recognize specific epitopes in its extracellular or intracellular domains. In research, these antibodies help investigate TMEFF2's involvement in pathways such as BMP (bone morphogenetic protein) signaling and receptor tyrosine kinase modulation. Clinically, TMEFF2 antibodies are explored for diagnostic applications (e.g., distinguishing cancer subtypes) and therapeutic development, including antibody-drug conjugates. However, challenges remain in optimizing specificity and validating cross-reactivity across species and isoforms.
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