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Rabbit Polyclonal VMP1 Antibody

  • 中文名: VMP1抗体
  • 别    名: EPG3; TANGO5; TMEM49
货号: IPDX12305
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是3篇关于VMP1抗体的参考文献及其摘要内容的简要概括:

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1. **文献名称**: *The autophagy-related protein VMP1 is required for efficient cellular invasion and cancer progression*

**作者**: Ropolo A, et al.

**摘要**: 该研究利用特异性VMP1抗体,揭示了VMP1在胰腺癌细胞自噬和侵袭转移中的关键作用。通过免疫荧光和Western blot实验,证明VMP1通过调控自噬小体形成促进肿瘤细胞的侵袭能力。

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2. **文献名称**: *VMP1 deficiency disrupts cellular calcium homeostasis and promotes apoptosis under endoplasmic reticulum stress*

**作者**: Grasso D, et al.

**摘要**: 研究通过抗体验证发现,VMP1敲除导致内质网应激下钙离子稳态失衡,并激活凋亡通路。VMP1抗体被用于检测内质网膜定位,表明其参与应激条件下的细胞存活调控。

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3. **文献名称**: *VMP1 interacts with viral proteins to facilitate viral replication and modulate host immune response*

**作者**: Molinari C, et al.

**摘要**: 利用VMP1特异性抗体进行免疫共沉淀实验,发现VMP1与特定病毒蛋白相互作用,促进病毒复制并抑制宿主天然免疫应答。研究揭示了VMP1在病毒感染中的双重功能。

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4. **文献名称**: *VMP1 mediates the formation of ER-phagyosomes during nutrient deprivation*

**作者**: Messinese L, et al.

**摘要**: 该研究通过VMP1抗体标记,证实VMP1在营养缺乏时介导内质网来源自噬小体(ER-phagyosome)的形成,并通过基因敲除实验证明其对细胞代谢适应性的重要性。

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以上文献均通过VMP1抗体开展蛋白定位、功能验证及分子机制研究,涉及肿瘤、病毒感染及细胞应激等领域。如需具体期刊或年份信息,可进一步补充检索条件。

背景信息

The Vacuole Membrane Protein 1 (VMP1) antibody is a critical tool for studying the role of VMP1. a transmembrane protein predominantly localized to endoplasmic reticulum (ER)-associated membranes and autophagosomal structures. First identified for its role in pancreas development, VMP1 is now recognized as a key regulator of autophagy, a cellular degradation process essential for maintaining homeostasis. It facilitates autophagosome formation by interacting with autophagy-related proteins (e.g., ATG16L1) and modulates ER membrane dynamics. Dysregulation of VMP1 is linked to pathologies including cancer, neurodegenerative diseases, and pancreatitis, making it a biomarker of interest. The VMP1 antibody enables researchers to detect and quantify VMP1 expression in tissues or cultured cells via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Its specificity is validated through knockdown/knockout controls to ensure accurate interpretation. Recent studies using VMP1 antibodies have revealed its involvement in tumor progression, drug resistance, and crosstalk between autophagy and apoptosis. As autophagy research expands, this antibody remains vital for elucidating VMP1’s molecular mechanisms and therapeutic potential.

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