| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | FCGR1A; FCRI; CD64A; IGFR1 |
| Entrez GeneID | 2209 |
| clone | 5F5F8 |
| WB Predicted band size | 42.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD64 (AA: extra 16-145) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是3篇关于TOP2B(拓扑异构酶IIβ)抗体的虚构参考文献示例(注：文献为假设性描述，实际文献需通过学术数据库检索)：
1. **文献名称**: "TOP2B as a therapeutic target in cancer: antibody-based inhibition strategies"
**作者**: Smith A, et al.
**摘要**: 研究报道了针对TOP2B的单克隆抗体在小鼠肿瘤模型中的抗增殖作用，表明通过抑制TOP2B活性可增强化疗药物敏感性，并减少耐药性。
2. **文献名称**: "Autoantibodies against TOP2B in neurodegenerative disorders"
**作者**: Chen L, et al.
**摘要**: 发现阿尔茨海默病患者血清中存在抗TOP2B自身抗体，可能与神经元DNA损伤和tau蛋白异常磷酸化相关，提示其在神经退行性疾病中的潜在生物标志物价值。
3. **文献名称**: "TOP2B antibody profiling in systemic lupus erythematosus"
**作者**: Gupta R, et al.
**摘要**: 系统性红斑狼疮(SLE)患者中抗TOP2B抗体的高表达与疾病活动度呈正相关，可能通过干扰DNA修复机制参与自身免疫反应。
---
**注**：以上内容为示例性虚构，真实文献请通过PubMed、Web of Science或Google Scholar检索关键词如"TOP2B antibody"、"anti-TOP2B autoantibody"等获取。
TOP2B (Topoisomerase II Beta) is a nuclear enzyme belonging to the type II topoisomerase family, which plays a critical role in DNA replication, transcription, and chromosome segregation by transiently breaking and rejoining double-stranded DNA to relieve torsional stress. Unlike its isoform TOP2A, which is predominantly expressed in proliferating cells and linked to cell cycle regulation, TOP2B is ubiquitously present in both dividing and non-dividing cells, particularly in neurons and post-mitotic tissues. This isoform is implicated in neurodevelopment, synaptic plasticity, and transcriptional regulation, with emerging roles in neurological disorders such as Alzheimer’s disease and ALS.
Antibodies targeting TOP2B are essential tools for studying its expression, localization, and function in diverse biological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate TOP2B's involvement in DNA repair mechanisms, chromatin remodeling, and responses to genotoxic stress. Additionally, TOP2B antibodies have clinical relevance in cancer research, as aberrant TOP2B expression or activity is associated with certain malignancies, including neuroblastoma and treatment-resistant tumors. Notably, TOP2B is a secondary target for some chemotherapeutic agents (e.g., etoposide), though its inhibition is often linked to off-target toxicity rather than therapeutic effects. Research utilizing these antibodies continues to clarify TOP2B's dual roles in maintaining genomic stability and contributing to disease pathogenesis, bridging molecular biology with therapeutic development.
×
