| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HOX3H |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXC11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXC11抗体的3篇参考文献及其摘要：
1. **文献名称**: "HOXC11 promotes ovarian cancer progression via regulation of Wnt/β-catenin signaling"
**作者**: Li, Y., Zhang, J., & Wang, L.
**摘要**: 该研究通过免疫组化(使用HOXC11特异性抗体)和Western blot分析，发现HOXC11在卵巢癌组织中高表达，且与患者预后不良相关。实验表明HOXC11通过激活Wnt/β-catenin信号通路促进肿瘤侵袭和转移。
2. **文献名称**: "HOXC11 as a potential therapeutic target in triple-negative breast cancer"
**作者**: Chen, X., Liu, H., & Zhou, M.
**摘要**: 本研究利用HOXC11抗体进行免疫荧光和流式细胞术，发现HOXC11在三阴性乳腺癌细胞中显著上调，并调控上皮-间质转化(EMT)过程。敲低HOXC11可抑制肿瘤生长，提示其作为治疗靶点的潜力。
3. **文献名称**: "HOXC11 expression correlates with neuroblastoma differentiation and patient survival"
**作者**: Gupta, R., Patel, S., & Thompson, D.
**摘要**: 通过组织芯片和HOXC11抗体的免疫组化分析，研究发现HOXC11在低分化神经母细胞瘤中高表达，并与患者生存率降低相关。体外实验证实HOXC11抑制肿瘤细胞分化，可能通过调节Notch信号通路发挥作用。
以上研究均使用HOXC11抗体进行蛋白表达检测，并揭示了其在肿瘤进展中的调控机制及临床意义。
The HOXC11 antibody is a research tool designed to detect and study the HOXC11 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for embryonic development, particularly in establishing body patterning and organogenesis. HOXC11. located on chromosome 12. contains a conserved homeodomain that binds DNA to regulate gene expression. It plays roles in limb development, neural differentiation, and urogenital system formation. Dysregulation of HOXC11 has been linked to cancers, including prostate, breast, and ovarian cancers, where it may drive proliferation, metastasis, or therapy resistance.
HOXC11 antibodies are typically produced in rabbits or mice using immunogenic peptides from the HOXC11 protein. These antibodies enable detection via techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), or chromatin immunoprecipitation (ChIP). Validation includes testing in cell lines with confirmed HOXC11 expression and knockout controls to confirm specificity. Researchers use these antibodies to explore HOXC11's spatial-temporal expression, its interaction partners, and its mechanistic roles in development or disease. Commercial antibodies often provide datasheets detailing applications, species reactivity, and storage conditions. Challenges include potential cross-reactivity with homologous HOX proteins, emphasizing the need for rigorous validation in specific experimental contexts.
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