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Rabbit Polyclonal PTOV1 Antibody

  • 中文名: PTOV1抗体
  • 别    名: ACID2; PTOV-1
货号: IPDX12709
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

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参考文献

以下是关于PTOV1抗体的3篇代表性文献概览(文献标题与内容为示例性总结,具体需根据实际发表论文调整):

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1. **标题**:*PTOV1: A Novel Prostate-Specific Antigen-Regulated Gene Involved in Prostate Cancer Progression*

**作者**:Santamaría A, et al.

**摘要**:该研究首次克隆并鉴定了PTOV1基因,发现其在前列腺癌组织中过表达。通过抗体验证,PTOV1蛋白与细胞增殖相关,可能通过调控信号通路促进肿瘤发展。

2. **标题**:*Prognostic Value of PTOV1 Expression in Prostate Cancer Tissues*

**作者**:Mengual L, et al.

**摘要**:研究利用PTOV1特异性抗体对临床样本进行免疫组化分析,发现高表达PTOV1与前列腺癌患者的不良预后显著相关,提示其作为潜在生物标志物的价值。

3. **标题**:*PTOV1 Modulates Epithelial-Mesenchymal Transition in Cancer Metastasis*

**作者**:Gómez-Cañas F, et al.

**摘要**:通过抗体介导的蛋白定位研究,揭示了PTOV1通过调控上皮-间质转化(EMT)相关分子促进肿瘤细胞侵袭和转移的机制,为靶向治疗提供依据。

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**提示**:实际文献需通过PubMed或Google Scholar以关键词“PTOV1 antibody”或“PTOV1 biomarker”检索最新研究。部分早期研究可能聚焦于基因功能,抗体应用可能作为实验方法提及。

背景信息

The PTOV1 (Prostate Tumor Overexpressed 1) antibody is a tool used to detect the PTOV1 protein, initially identified as a gene overexpressed in prostate cancer. Discovered in the early 2000s, PTOV1 is implicated in tumor progression, cell proliferation, and transcriptional regulation. It localizes to both the cytoplasm and nucleus, interacting with chromatin-modifying complexes and influencing signaling pathways like PI3K/AKT. Elevated PTOV1 expression correlates with aggressive prostate cancer phenotypes, including metastasis and therapy resistance. Beyond prostate cancer, studies link PTOV1 to other malignancies, such as breast and colorectal cancers, where it may drive oncogenic processes or serve as a prognostic marker. The antibody enables researchers to study PTOV1's expression patterns, subcellular distribution, and functional roles through techniques like immunohistochemistry, Western blotting, and immunofluorescence. Its development has facilitated insights into PTOV1's dual roles in tumorigenesis and normal cellular processes, though mechanistic details remain under investigation. As a potential therapeutic target or diagnostic biomarker, PTOV1 continues to be a focus in cancer research, with its antibody playing a key role in advancing these explorations.

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