| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | EST155051 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ABCA6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABCA6抗体的3篇文献示例(内容为虚构示例，仅供参考)：
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1. **文献名称**: *ABCA6 expression and its role in hepatic lipid metabolism*
**作者**: Smith J, et al. (2018)
**摘要**: 本研究通过开发特异性ABCA6抗体，揭示了其在肝细胞中的定位及功能。Western blot和免疫荧光实验表明，ABCA6参与调控胆固醇外排，其表达水平与高脂饮食小鼠的肝脏脂质沉积呈负相关。
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2. **文献名称**: *Characterization of a monoclonal antibody against human ABCA6*
**作者**: Zhang L, et al. (2020)
**摘要**: 文章报道了一种高亲和力单克隆抗体的制备与验证，该抗体可特异性识别ABCA6蛋白的胞外结构域。研究证实，ABCA6在巨噬细胞中高表达，并可能通过调节细胞膜磷脂分布影响炎症反应。
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3. **文献名称**: *ABCA6 genetic variants and antibody-based detection in cardiovascular disease*
**作者**: Tanaka K, et al. (2021)
**摘要**: 通过免疫组化分析临床样本，发现ABCA6在动脉粥样硬化斑块中的表达显著升高。研究利用商业化ABCA6抗体验证其与心血管疾病风险的关联，提示其作为潜在生物标志物的可能性。
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(注：以上文献及摘要均为模拟内容，实际引用需查询真实数据库如PubMed、Google Scholar等。)
The ABCA6 antibody is a tool used to study the ATP-binding cassette subfamily A member 6 (ABCA6), a protein encoded by the ABCA6 gene in humans. ABCA6 belongs to the ATP-binding cassette (ABC) transporter superfamily, which is characterized by transmembrane proteins that hydrolyze ATP to transport various substrates across cellular membranes. While ABCA6's exact physiological role remains unclear, it is hypothesized to participate in lipid metabolism, potentially regulating cholesterol or phospholipid transport. This protein is primarily expressed in the liver and may influence cellular lipid homeostasis, though its function is less understood compared to other ABCA family members like ABCA1 (critical in cholesterol efflux) or ABCA4 (involved in retinal metabolism).
Research on ABCA6 is limited, but studies suggest associations with metabolic disorders. For instance, genetic variations in ABCA6 have been linked to altered serum cholesterol levels and cardiovascular diseases, such as atherosclerosis. ABCA6 antibodies enable detection and localization of the protein in tissues or cell lines, aiding investigations into its expression patterns under physiological or pathological conditions. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, or flow cytometry. Despite its potential relevance, ABCA6 remains understudied, partly due to functional redundancy within the ABCA subfamily and a lack of definitive mechanistic insights. Ongoing research aims to clarify its biological role and therapeutic implications in lipid-related diseases.
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