| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AGF; ARP5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ANGPTL6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ANGPTL6抗体的3篇代表性文献示例(注：文献信息为模拟概括，实际文献需通过学术数据库查询)：
1. **文献名称**：*ANGPTL6 regulates adipose tissue metabolism and acts as a therapeutic target in obesity*
**作者**：Kim, J. et al.
**摘要**：研究揭示了ANGPTL6在脂肪组织能量代谢中的作用，并开发了一种特异性抗体，证明其可改善肥胖小鼠模型的胰岛素抵抗和脂质代谢异常。
2. **文献名称**：*Anti-ANGPTL6 antibody inhibits tumor angiogenesis and suppresses breast cancer progression*
**作者**：Zhang, Y. et al.
**摘要**：该研究通过制备人源化ANGPTL6单克隆抗体，发现其能有效抑制肿瘤血管生成，降低乳腺癌小鼠模型的肿瘤生长和转移，提示其作为抗癌药物的潜力。
3. **文献名称**：*ANGPTL6 modulates cardiac hypertrophy via ERK signaling: Implications for antibody-based therapy*
**作者**：Sato, K. et al.
**摘要**：研究证明ANGPTL6通过ERK通路参与病理性心肌肥厚，使用中和抗体阻断ANGPTL6可显著减轻小鼠心脏肥厚表型，为心血管疾病治疗提供新策略。
**提示**：以上为示例性概括，实际文献需在PubMed、Web of Science等平台以“ANGPTL6 antibody”为关键词检索，并关注近年高影响力期刊(如*Nature Metabolism*、*Circulation Research*等)。
**Background of ANGPTL6 Antibodies**
ANGPTL6 (angiopoietin-like protein 6), also known as angiopoietin-related growth factor (AGF), is a secreted glycoprotein belonging to the angiopoietin-like protein family. It is primarily expressed in the liver and endothelial cells, playing roles in metabolic regulation, angiogenesis, and tissue repair. Structurally, ANGPTL6 contains an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, enabling interactions with extracellular receptors to modulate signaling pathways.
Research highlights its dual functions: promoting energy expenditure to combat obesity and enhancing insulin sensitivity, while also stimulating vascular growth in contexts like tissue injury or tumorigenesis. Dysregulation of ANGPTL6 is linked to metabolic disorders, cardiovascular diseases, and cancer progression.
ANGPTL6 antibodies are tools developed to study the protein's expression, localization, and mechanistic roles. They are used in immunoassays (e.g., ELISA, Western blot, immunohistochemistry) to quantify ANGPTL6 levels in biological samples or block its activity in functional studies. Therapeutic potential is also explored; neutralizing antibodies may inhibit ANGPTL6-driven pathways in metabolic syndromes or cancer. However, challenges remain in understanding tissue-specific functions and optimizing antibody specificity for clinical applications. Current studies focus on clarifying its physiological and pathological impacts to guide targeted therapies.
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