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Rabbit Polyclonal MATN2 Antibody

  • 中文名: MATN2抗体
  • 别    名: nan
货号: IPDX12796
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human MATN2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇与MATN2抗体相关的文献摘要示例(部分信息为模拟概括,实际引用时请核实原文):

1. **文献名称**:*Matrilin-2 (MATN2) in extracellular matrix remodeling and cancer progression*

**作者**:Smith A, et al.

**摘要**:研究分析了MATN2在肿瘤微环境中的表达及功能,通过制备特异性MATN2抗体,证实其在乳腺癌细胞侵袭转移中通过调控基质金属蛋白酶活性发挥作用。

2. **文献名称**:*Characterization of a novel monoclonal antibody against human MATN2 for immunohistochemical applications*

**作者**:Zhang L, et al.

**摘要**:报道一种新型MATN2单克隆抗体的开发与验证,该抗体可用于石蜡包埋组织切片的免疫组化染色,并应用于骨关节炎患者的软骨组织检测MATN2异常沉积。

3. **文献名称**:*MATN2 interacts with TGF-β signaling to modulate fibrosis in diabetic nephropathy*

**作者**:Wang Y, et al.

**摘要**:利用MATN2抗体进行Western blot和免疫荧光实验,发现MATN2通过结合TGF-β1调控肾纤维化通路,提示其作为糖尿病肾病治疗靶点的潜力。

4. **文献名称**:*MATN2 deficiency disrupts cerebral cortex development in mice*

**作者**:Chen H, et al.

**摘要**:通过MATN2基因敲除小鼠模型及抗体标记技术,揭示MATN2在胚胎期大脑皮层神经元迁移中的关键作用,其缺失导致皮层结构异常。

(注:以上为模拟生成的文献概要,实际文献需通过PubMed、Web of Science等数据库检索确认。)

背景信息

The MATN2 antibody is a research tool designed to detect matrilin-2 (MATN2), a protein belonging to the matrilin family of extracellular matrix (ECM) components. Matrilins are involved in ECM assembly, tissue development, and cellular interactions, with MATN2 specifically expressed in tissues like cartilage, heart, and blood vessels. It plays roles in modulating cell adhesion, signaling, and tissue remodeling by interacting with other ECM proteins, such as collagen and proteoglycans. MATN2 antibodies are commonly used in studies investigating musculoskeletal disorders, cardiovascular diseases, or cancer, where ECM dysregulation is implicated. These antibodies enable detection of MATN2 expression patterns via techniques like Western blot, immunohistochemistry, or immunofluorescence. Recent studies highlight MATN2's potential involvement in tumor progression, fibrosis, and cartilage repair, making its antibody a valuable tool for mechanistic and diagnostic research. However, commercial availability and validation data vary, requiring careful selection based on target epitopes, species reactivity (human, mouse, etc.), and application-specific performance. Ongoing research continues to explore MATN2's functional diversity and therapeutic relevance.

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