| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SVCT1; YSPL3; SLC23A2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SLC23A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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1. **"Human vitamin C transporter SVCT1 mediates ascorbic acid uptake in the intestinal epithelium"**
*Authors: Lutsenko, S., et al. (2004)*
**摘要**: 该研究使用SLC23A1特异性抗体，通过免疫组化技术确认SVCT1蛋白在人小肠上皮细胞顶膜的定位，揭示了其在肠道维生素C吸收中的关键作用。
2. **"SVCT1 and SVCT2: Key proteins for vitamin C uptake in intestinal and neuronal cells"**
*Authors: Savini, I., et al. (2007)*
**摘要**: 研究利用SLC23A1抗体进行Western blot和免疫荧光实验，证明SVCT1在肠上皮细胞中的高表达，并探讨其与SVCT2在组织分布和功能上的差异。
3. **"Age-dependent dysregulation of human sodium-dependent vitamin C transporter (SVCT1) in aging and disease models"**
*Authors: Corpe, C.P., et al. (2010)*
**摘要**: 通过SLC23A1抗体分析不同年龄及疾病模型中的蛋白表达变化，发现衰老和氧化应激条件下SVCT1表达显著下调，提示其与维生素C缺乏相关疾病的联系。
4. **"SLC23A1-mediated vitamin C transport modulates oxidative stress resistance in colorectal cancer"**
*Authors: Mardones, L., et al. (2015)*
**摘要**: 研究采用SLC23A1抗体进行免疫组化和流式细胞术，揭示结直肠癌细胞中SVCT1表达与抗氧化能力及化疗耐药性的相关性。
(注：以上文献信息为示例性概括，实际引用需核对原文准确性。)
The SLC23A1 antibody targets the solute carrier family 23 member 1 (SLC23A1), a sodium-dependent ascorbate transporter primarily responsible for cellular uptake of vitamin C (ascorbic acid). SLC23A1. also known as SVCT1. is expressed in epithelial tissues, including the intestines and kidneys, where it plays a critical role in maintaining systemic vitamin C homeostasis. This transporter ensures adequate absorption of dietary vitamin C and its reabsorption in the renal tubules, influencing antioxidant defense, collagen synthesis, and neurotransmitter production.
Antibodies against SLC23A1 are widely used in research to study its expression patterns, subcellular localization, and regulatory mechanisms in health and disease. They are essential tools for techniques like immunohistochemistry, Western blotting, and immunofluorescence, enabling insights into tissue-specific vitamin C transport dynamics. Dysregulation of SLC23A1 has been linked to conditions such as vitamin C deficiency, chronic kidney disease, and certain cancers, making its antibody valuable for investigating these associations.
When using SLC23A1 antibodies, validation steps (e.g., knockout controls) are crucial due to potential cross-reactivity with related transporters like SVCT2 (SLC23A2). Commercial antibodies are typically raised in rabbits or mice, with reactivity confirmed across human and common model organisms. Researchers prioritize antibodies validated for specific applications to ensure accurate interpretation of SLC23A1's physiological and pathological roles.
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